MRT68921 HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555220

CAS#: 2080306-21-2 (HCl)

Description: MRT68921 is an inhibitor of ULK1 and ULK2 (IC50s = 2.9 and 1.1 nM, respectively).


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 1950
5g
USD 8950
Size
Price

100mg
USD 750
1g
USD 3250
Size
Price

200mg
USD 1250
2g
USD 4950

MRT68921 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555220
Name: MRT68921 HCl
CAS#: 2080306-21-2 (HCl)
Chemical Formula: C27H37ClN4O
Exact Mass:
Molecular Weight: 469.07
Elemental Analysis: C, 69.14; H, 7.95; Cl, 7.56; N, 11.94; O, 3.41


Related CAS #: 1190379-70-4 (free base)   2080306-21-2 (HCl)    

Synonym: MRT68921 HCl; MRT68921 hydrochloride; MRT68921; MRT 68921; MRT-68921.

IUPAC/Chemical Name: Cyclobutanecarboxylic acid {3-[2-cyclopropyl-5-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ylamino)-phenylamino]-propyl}-amide hydrochloride

InChi Key: LCESSSCGCRQOKI-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H36N4O.ClH/c1-31-15-12-21-16-23(9-8-22(21)18-31)30-24-10-11-25(19-6-7-19)26(17-24)28-13-3-14-29-27(32)20-4-2-5-20;/h8-11,16-17,19-20,28,30H,2-7,12-15,18H2,1H3,(H,29,32);1H

SMILES Code: O=C(C1CCC1)NCCCNC2=CC(NC3=CC4=C(CN(C)CC4)C=C3)=CC=C2C5CC5.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Petherick KJ, Conway OJ, Mpamhanga C, Osborne SA, Kamal A, Saxty B, Ganley IG. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. doi: 10.1074/jbc.C114.627778. Erratum in: J Biol Chem. 2015 Nov 27;290(48):28726. PubMed PMID: 25833948; PubMed Central PMCID: PMC4416842.