Calcium Fusarate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527851

CAS#: 21813-99-0

Description: Calcium Fusarate is an inhibitor of dopamine beta-hydroxylase, the enzyme that converts dopamine to norepinephrine, also inhibiting cell proliferation and DNA synthesis.


Chemical Structure

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Calcium Fusarate
CAS# 21813-99-0

Theoretical Analysis

MedKoo Cat#: 527851
Name: Calcium Fusarate
CAS#: 21813-99-0
Chemical Formula: C20H24CaN2O4
Exact Mass: 396.14
Molecular Weight: 396.500
Elemental Analysis: C, 60.59; H, 6.10; Ca, 10.11; N, 7.07; O, 16.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Calcium Fusarate

IUPAC/Chemical Name: Calcium 5-butylpyridine-2-carboxylate

InChi Key: XMRLUNALKLDUPT-UHFFFAOYSA-L

InChi Code: InChI=1S/2C10H13NO2.Ca/c2*1-2-3-4-8-5-6-9(10(12)13)11-7-8;/h2*5-7H,2-4H2,1H3,(H,12,13);/q;;+2/p-2

SMILES Code: O=C(C1=NC=C(CCCC)C=C1)[O-].O=C(C2=NC=C(CCCC)C=C2)[O-].[Ca+2]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 396.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhao YM, Cheng YX, Ma YN, Chen CJ, Xu FR, Dong X. Role of Phenolic Acids from the Rhizosphere Soils of Panax notoginseng as a Double-Edge Sword in the Occurrence of Root-Rot Disease. Molecules. 2018 Apr 3;23(4). pii: E819. doi: 10.3390/molecules23040819. PubMed PMID: 29614031.

2: Sao Emani C, Williams MJ, Wiid IJ, Baker B, Carolis C. Compounds with Potential Activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02236-17. doi: 10.1128/AAC.02236-17. Print 2018 Apr. PubMed PMID: 29437626.

3: Reveglia P, Cinelli T, Cimmino A, Masi M, Evidente A. The main phytotoxic metabolite produced by a strain of Fusarium oxysporum inducing grapevine plant declining in Italy. Nat Prod Res. 2017 Dec 13:1-10. doi: 10.1080/14786419.2017.1415897. [Epub ahead of print] PubMed PMID: 29237292.

4: Janevska S, Tudzynski B. Secondary metabolism in Fusarium fujikuroi: strategies to unravel the function of biosynthetic pathways. Appl Microbiol Biotechnol. 2018 Jan;102(2):615-630. doi: 10.1007/s00253-017-8679-5. Epub 2017 Dec 4. Review. PubMed PMID: 29204899.

5: Sun Y, Wang Y, Han LR, Zhang X, Feng JT. Antifungal Activity and Action Mode of Cuminic Acid from the Seeds of Cuminum cyminum L. against Fusarium oxysporum f. sp. Niveum (FON) Causing Fusarium Wilt on Watermelon. Molecules. 2017 Nov 30;22(12). pii: E2053. doi: 10.3390/molecules22122053. PubMed PMID: 29189726.

6: Simonetti E, Roberts IN, Montecchia MS, Gutierrez-Boem FH, Gomez FM, Ruiz JA. A novel Burkholderia ambifaria strain able to degrade the mycotoxin fusaric acid and to inhibit Fusarium spp. growth. Microbiol Res. 2018 Jan;206:50-59. doi: 10.1016/j.micres.2017.09.008. Epub 2017 Sep 22. PubMed PMID: 29146260.

7: Bauer B, Göderz AL, Braumüller H, Neudörfl JM, Röcken M, Wieder T, Schmalz HG. Methyl Fumarate-Derived Iron Carbonyl Complexes (FumET-CORMs) as Powerful Anti-inflammatory Agents. ChemMedChem. 2017 Dec 7;12(23):1927-1930. doi: 10.1002/cmdc.201700488. Epub 2017 Nov 2. PubMed PMID: 29094797.

8: Niehaus EM, Rindermann L, Janevska S, Münsterkötter M, Güldener U, Tudzynski B. Analysis of the global regulator Lae1 uncovers a connection between Lae1 and the histone acetyltransferase HAT1 in Fusarium fujikuroi. Appl Microbiol Biotechnol. 2018 Jan;102(1):279-295. doi: 10.1007/s00253-017-8590-0. Epub 2017 Oct 28. PubMed PMID: 29080998.

9: Niehaus EM, Kim HK, Münsterkötter M, Janevska S, Arndt B, Kalinina SA, Houterman PM, Ahn IP, Alberti I, Tonti S, Kim DW, Sieber CMK, Humpf HU, Yun SH, Güldener U, Tudzynski B. Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles. PLoS Pathog. 2017 Oct 26;13(10):e1006670. doi: 10.1371/journal.ppat.1006670. eCollection 2017 Oct. PubMed PMID: 29073267; PubMed Central PMCID: PMC5675463.

10: Crutcher FK, Puckhaber LS, Stipanovic RD, Bell AA, Nichols RL, Lawrence KS, Liu J. Microbial Resistance Mechanisms to the Antibiotic and Phytotoxin Fusaric Acid. J Chem Ecol. 2017 Oct;43(10):996-1006. doi: 10.1007/s10886-017-0889-x. Epub 2017 Oct 6. PubMed PMID: 28986689.

11: Singh VK, Singh HB, Upadhyay RS. Role of fusaric acid in the development of 'Fusarium wilt' symptoms in tomato: Physiological, biochemical and proteomic perspectives. Plant Physiol Biochem. 2017 Sep;118:320-332. doi: 10.1016/j.plaphy.2017.06.028. Epub 2017 Jun 28. PubMed PMID: 28683401.

12: Li X, Zhang ZL, Wang HF. Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways. Biomed Pharmacother. 2017 Sep;93:130-145. doi: 10.1016/j.biopha.2017.06.002. Epub 2017 Jun 16. PubMed PMID: 28624424.

13: Dhani S, Nagiah S, Naidoo DB, Chuturgoon AA. Fusaric Acid immunotoxicity and MAPK activation in normal peripheral blood mononuclear cells and Thp-1 cells. Sci Rep. 2017 Jun 8;7(1):3051. doi: 10.1038/s41598-017-03183-0. PubMed PMID: 28596589; PubMed Central PMCID: PMC5465181.

14: Crutcher FK, Puckhaber LS, Bell AA, Liu J, Duke SE, Stipanovic RD, Nichols RL. Detoxification of Fusaric Acid by the Soil Microbe Mucor rouxii. J Agric Food Chem. 2017 Jun 21;65(24):4989-4992. doi: 10.1021/acs.jafc.7b01655. Epub 2017 Jun 7. PubMed PMID: 28538103.

15: Mao Y, Jiang B, Peng Q, Liu W, Lin Y, Xie D, He X, Li S. Cloning and characterization of WRKY gene homologs in Chieh-qua (Benincasa hispida Cogn. var. Chieh-qua How) and their expression in response to fusaric acid treatment. 3 Biotech. 2017 May;7(1):86. doi: 10.1007/s13205-017-0711-z. Epub 2017 May 13. PubMed PMID: 28501986; PubMed Central PMCID: PMC5429887.

16: Lugtenberg B, Rozen DE, Kamilova F. Wars between microbes on roots and fruits. F1000Res. 2017 Mar 27;6:343. doi: 10.12688/f1000research.10696.1. eCollection 2017. Review. PubMed PMID: 28408980; PubMed Central PMCID: PMC5373426.

17: Ghazi T, Nagiah S, Tiloke C, Sheik Abdul N, Chuturgoon AA. Fusaric Acid Induces DNA Damage and Post-Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG(2) ) Cells. J Cell Biochem. 2017 Nov;118(11):3866-3874. doi: 10.1002/jcb.26037. Epub 2017 May 19. PubMed PMID: 28387973.

18: Zhou J, Wang M, Sun Y, Gu Z, Wang R, Saydin A, Shen Q, Guo S. Nitrate Increased Cucumber Tolerance to Fusarium Wilt by Regulating Fungal Toxin Production and Distribution. Toxins (Basel). 2017 Mar 11;9(3). pii: E100. doi: 10.3390/toxins9030100. PubMed PMID: 28287458; PubMed Central PMCID: PMC5371855.

19: Chen Z, Luo Q, Wang M, Chen B. A Rapid Method with UPLC for the Determination of Fusaric Acid in Fusarium Strains and Commercial Food and Feed Products. Indian J Microbiol. 2017 Mar;57(1):68-74. doi: 10.1007/s12088-016-0617-1. Epub 2016 Aug 23. PubMed PMID: 28148981; PubMed Central PMCID: PMC5243244.

20: López-Díaz C, Rahjoo V, Sulyok M, Ghionna V, Martín-Vicente A, Capilla J, Di Pietro A, López-Berges MS. Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts. Mol Plant Pathol. 2018 Feb;19(2):440-453. doi: 10.1111/mpp.12536. Epub 2017 Mar 15. PubMed PMID: 28093838.