WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562449
CAS#: 1426944-49-1
Description: HBX19818 is a selective inhibitor of USP7.
MedKoo Cat#: 562449
Name: HBX19818
CAS#: 1426944-49-1
Chemical Formula: C25H28ClN3O
Exact Mass: 421.1921
Molecular Weight: 421.969
Elemental Analysis: C, 71.16; H, 6.69; Cl, 8.40; N, 9.96; O, 3.79
Synonym: HBX19818; HBX-19818; HBX 19818;
IUPAC/Chemical Name: 9-Chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-2-acridinecarboxamide
InChi Key: ZCALMLVWZSQGGR-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H28ClN3O/c1-29(17-18-8-3-2-4-9-18)15-7-14-27-25(30)19-12-13-23-21(16-19)24(26)20-10-5-6-11-22(20)28-23/h2-4,8-9,12-13,16H,5-7,10-11,14-15,17H2,1H3,(H,27,30)
SMILES Code: O=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(C)CC4=CC=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM. |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.5 | 29.62 | |
| Ethanol | 5.0 | 0.47 | |
| Water | 5.0 | 0.47 |
The following data is based on the product molecular weight 421.969 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
