Parathion-methyl

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MedKoo CAT#: 341249

CAS#: 298-00-0

Description: Parathion methyl, or methyl parathion, is an organophosphate pesticide and insecticide, possessing a organothiophosphate group


Price and Availability

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Pricing updated 2020-07-11. Prices are subject to change without notice.

Parathion-methyl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 341249
Name: Parathion-methyl
CAS#: 298-00-0
Chemical Formula: C8H10NO5PS
Exact Mass: 263.0017
Molecular Weight: 263.2038
Elemental Analysis: C, 36.51; H, 3.83; N, 5.32; O, 30.39; P, 11.77; S, 12.18


Synonym: Parathion-methyl; BAY 11405; BAY-11405; BAY11405.

IUPAC/Chemical Name: Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester

InChi Key: RLBIQVVOMOPOHC-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H10NO5PS/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3

SMILES Code: COP(OC)(Oc1ccc([N+]([O-])=O)cc1)=S


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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2: Jiang B, Dong P, Zheng J. A novel amperometric biosensor based on covalently attached multilayer assemblies of gold nanoparticles, diazo-resins and acetylcholinesterase for the detection of organophosphorus pesticides. Talanta. 2018 Jun 1;183:114-121. doi: 10.1016/j.talanta.2018.02.016. Epub 2018 Feb 15. PubMed PMID: 29567153.

3: Notardonato I, Salimei E, Russo MV, Avino P. Simultaneous determination of organophosphorus pesticides and phthalates in baby food samples by ultrasound-vortex-assisted liquid-liquid microextraction and GC-IT/MS. Anal Bioanal Chem. 2018 Mar 17. doi: 10.1007/s00216-018-0986-x. [Epub ahead of print] PubMed PMID: 29549507.

4: Hernandez-Cortes D, Alvarado-Cruz I, Solís-Heredia MJ, Quintanilla-Vega B. Epigenetic modulation of Nrf2 and Ogg1 gene expression in testicular germ cells by methyl parathion exposure. Toxicol Appl Pharmacol. 2018 May 1;346:19-27. doi: 10.1016/j.taap.2018.03.010. Epub 2018 Mar 11. PubMed PMID: 29540303.

5: Sobjak TM, Romão S, Cazarolli LH, Sampaio SC, Remor MB, Guimarães ATB. Evaluation of the antioxidant system and neurotoxic effects observed in Rhamdia branneri (Teleostei: Heptapteridae) sampled from streams of the lower Iguazu River basin. Ecotoxicol Environ Saf. 2018 Jul 15;155:162-170. doi: 10.1016/j.ecoenv.2018.02.063. Epub 2018 Mar 6. PubMed PMID: 29522881.

6: Du F, Fung YS. Dual-opposite multi-walled carbon nanotube modified carbon fiber microelectrode for microfluidic chip-capillary electrophoresis determination of methyl parathion metabolites in human urine. Electrophoresis. 2018 Mar 3. doi: 10.1002/elps.201700470. [Epub ahead of print] PubMed PMID: 29500834.

7: de Souza PR, de Souza KS, de Assis CRD, de Araújo MC, Silva KCC, de Fátima Xavier da Silva J, Ferreira ACM, da Silva VL, Adam ML, de Carvalho LB Jr., de Souza Bezerra R. Acetylcholinesterase of mangrove oyster Crassostrea rhizophorae: A highly thermostable enzyme with promising features for estuarine biomonitoring. Aquat Toxicol. 2018 Apr;197:109-121. doi: 10.1016/j.aquatox.2018.02.008. Epub 2018 Feb 12. PubMed PMID: 29462762.

8: Shen M, Fu L, Tang J, Liu M, Song Y, Tian F, Zhao Z, Zhang Z, Dionysiou DD. Microwave hydrothermal-assisted preparation of novel spinel-NiFe(2)O(4)/natural mineral composites as microwave catalysts for degradation of aquatic organic pollutants. J Hazard Mater. 2018 May 15;350:1-9. doi: 10.1016/j.jhazmat.2018.02.014. Epub 2018 Feb 6. PubMed PMID: 29448208.

9: Li Y, Liu J, Zhang Y, Gu M, Wang D, Dang YY, Ye BC, Li Y. A robust electrochemical sensing platform using carbon paste electrode modified with molecularly imprinted microsphere and its application on methyl parathion detection. Biosens Bioelectron. 2018 May 30;106:71-77. doi: 10.1016/j.bios.2018.01.057. Epub 2018 Jan 31. PubMed PMID: 29414092.

10: Chormey DS, Öztürk Er E, Erarpat S, Özzeybek G, Arı B, Bakirdere S. A novel analytical approach for the determination of parathion methyl in water: quadrupole isotope dilution mass spectrometry-dispersive liquid-liquid microextraction using multivariate optimization. Analyst. 2018 Feb 26;143(5):1141-1146. doi: 10.1039/c7an02014g. PubMed PMID: 29393311.

11: Fuentes-Delgado VH, Martínez-Saldaña MC, Rodríguez-Vázquez ML, Reyes-Romero MA, Reyes-Sánchez JL, Jaramillo-Juárez F. Renal damage induced by the pesticide methyl parathion in male Wistar rats. J Toxicol Environ Health A. 2018;81(6):130-141. doi: 10.1080/15287394.2017.1394948. Epub 2018 Jan 10. PubMed PMID: 29319433.

12: Sun L, Liu H, Gao X, Chen W, Huang K, Zhang S. Isolation of monocrotophos-degrading strain Sphingobiumsp. YW16 and cloning of its TnopdA. Environ Sci Pollut Res Int. 2018 Feb;25(5):4942-4950. doi: 10.1007/s11356-017-0718-3. Epub 2017 Dec 4. PubMed PMID: 29204940.

13: Jacquet P, Hiblot J, Daudé D, Bergonzi C, Gotthard G, Armstrong N, Chabrière E, Elias M. Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase. Sci Rep. 2017 Dec 1;7(1):16745. doi: 10.1038/s41598-017-16841-0. PubMed PMID: 29196634; PubMed Central PMCID: PMC5711954.

14: Fentabil M, Gebremedhin M, Purdon JG, Cochrane L, Goldman VS. Degradation of pesticides with RSDL(®) (reactive skin decontamination lotion kit) lotion: LC-MS investigation. Toxicol Lett. 2017 Nov 8. pii: S0378-4274(17)31451-0. doi: 10.1016/j.toxlet.2017.11.003. [Epub ahead of print] PubMed PMID: 29128639.

15: Lyagin IV, Efremenko EN. Biomolecular engineering of biocatalysts hydrolyzing neurotoxic organophosphates. Biochimie. 2018 Jan;144:115-121. doi: 10.1016/j.biochi.2017.10.023. Epub 2017 Oct 31. PubMed PMID: 29097283.

16: Wu L, Chládková B, Lechtenfeld OJ, Lian S, Schindelka J, Herrmann H, Richnow HH. Characterizing chemical transformation of organophosphorus compounds by (13)C and (2)H stable isotope analysis. Sci Total Environ. 2018 Feb 15;615:20-28. doi: 10.1016/j.scitotenv.2017.09.233. Epub 2017 Oct 17. PubMed PMID: 28961438.

17: Pano-Farias NS, Ceballos-Magaña SG, Muñiz-Valencia R, Gonzalez J. Validation and assessment of matrix effect and uncertainty of a gas chromatography coupled to mass spectrometry method for pesticides in papaya and avocado samples. J Food Drug Anal. 2017 Jul;25(3):501-509. doi: 10.1016/j.jfda.2016.09.005. Epub 2016 Nov 5. PubMed PMID: 28911635.

18: Hu TT, Lu CM, Li H, Zhang ZX, Zhao YH, Li J. Determination of Eleven Organophosphorus Pesticide Residues in Textiles by Using HPLC-HRMS. Anal Sci. 2017;33(9):1027-1032. doi: 10.2116/analsci.33.1027. PubMed PMID: 28890486.

19: García-Reyes S, Yáñez-Ocampo G, Wong-Villarreal A, Rajaretinam RK, Thavasimuthu C, Patiño R, Ortiz-Hernández ML. Partial characterization of a biosurfactant extracted from Pseudomonas sp. B0406 that enhances the solubility of pesticides. Environ Technol. 2017 Aug 22:1-10. doi: 10.1080/21622515.2017.1363295. [Epub ahead of print] PubMed PMID: 28783001.

20: Seifert J. Embryo yolk sac membrane kynurenine formamidase of l-tryptophan to NAD(+) pathway as a primary target for organophosphorus insecticides (OPI) in OPI-induced NAD-associated avian teratogenesis. Toxicol In Vitro. 2017 Oct;44:357-360. doi: 10.1016/j.tiv.2017.08.001. Epub 2017 Aug 4. PubMed PMID: 28782636.