WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558214
CAS#: 41928-02-3
Description: 10-Hydroxyyohimbine is a biochemical.
MedKoo Cat#: 558214
Name: 10-Hydroxyyohimbine
CAS#: 41928-02-3
Chemical Formula: C21H26N2O4
Exact Mass: 370.1893
Molecular Weight: 370.449
Elemental Analysis: C, 68.09; H, 7.07; N, 7.56; O, 17.28
This product is not in stock, which may be available by custom synthesis.
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Synonym: 10-Hydroxyyohimbine
IUPAC/Chemical Name: methyl (1S,15R,18S,19R,20S)-7,18-dihydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
InChi Key: XKJJSWXADRRQKQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H26N2O4/c1-27-21(26)19-14-9-17-20-13(15-8-12(24)3-4-16(15)22-20)6-7-23(17)10-11(14)2-5-18(19)25/h3-4,8,11,14,17-19,22,24-25H,2,5-7,9-10H2,1H3
SMILES Code: COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=C(N4)C=CC(=C5)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 370.449 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Duflos A, Redoules F, Fahy J, Jacquesy JC, Jouannetaud MP. Hydroxylation of yohimbine in superacidic media: one-step access to human metabolites 10 and 11-hydroxyyohimbine. J Nat Prod. 2001 Feb;64(2):193-5. PubMed PMID: 11429998.
2: Berlan M, Le Verge R, Galitzky J, Le Corre P. Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine. Br J Pharmacol. 1993 Apr;108(4):927-32. PubMed PMID: 8097957; PubMed Central PMCID: PMC1908160.
3: MEYERS E, PAN SC. Microbial transformation of Rauwolfia alkaloids. II. 10-Hydroxyyohimbine. J Bacteriol. 1961 Mar;81:504-5. PubMed PMID: 13770059; PubMed Central PMCID: PMC279038.
