A-940894

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555208

CAS#: 1027330-82-0 (free base)

Description: A-940894 is a potent histamine H4 receptor antagonist with anti-inflammatory properties. A-940894 potently binds to both human and rat histamine H4 receptors and exhibits considerably lower affinity for the human histamine H1, H2 or H3 receptors. It potently blocked histamine-evoked calcium mobilization in the fluorometric imaging plate reader assays and inhibited histamine-induced shape change of mouse bone marrow-derived mast cells and chemotaxis of human eosinophils in vitro. A-940894 has good pharmacokinetic properties, including half-life and oral bioavailability in rats and mice.


Price and Availability

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A-940894 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555208
Name: A-940894
CAS#: 1027330-82-0 (free base)
Chemical Formula: C17H21N5
Exact Mass: 295.1797
Molecular Weight: 295.39
Elemental Analysis: C, 69.12; H, 7.17; N, 23.71


Related CAS #: 1027330-82-0 (free base)   1072114-55-6 (maleate)    

Synonym: A-940894; A 940894; A940894.

IUPAC/Chemical Name: 4-piperazin-1-yl-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine

InChi Key: KUZRWWLVBUPCRK-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H21N5/c18-17-20-15-13-6-2-1-4-12(13)5-3-7-14(15)16(21-17)22-10-8-19-9-11-22/h1-2,4,6,19H,3,5,7-11H2,(H2,18,20,21)

SMILES Code: NC1=NC(N2CCNCC2)=C(CCCC3=CC=CC=C34)C4=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

A-940894 is a potent and selective histamine H4 receptor antagonist with pharmacokinetic properties suitable for long-term in vivo testing and could serve as a useful tool for the further characterization of histamine H4 receptor pharmacology.


References

1: Strakhova MI, Cuff CA, Manelli AM, Carr TL, Witte DG, Baranowski JL, Vortherms
TA, Miller TR, Rundell L, McPherson MJ, Adair RM, Brito AA, Bettencourt BM, Yao
BB, Wetter JM, Marsh KC, Liu H, Cowart MD, Brioni JD, Esbenshade TA. In vitro and
in vivo characterization of A-940894: a potent histamine H4 receptor antagonist
with anti-inflammatory properties. Br J Pharmacol. 2009 May;157(1):44-54. doi:
10.1111/j.1476-5381.2009.00236.x. PubMed PMID: 19413570; PubMed Central PMCID:
PMC2697788.