WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562411
CAS#: 147751-31-3
Description: HDL376 is an inhibitor of scavenger receptor BI (SR-BI).
MedKoo Cat#: 562411
Name: HDL376
CAS#: 147751-31-3
Chemical Formula: C12H17ClN2S
Exact Mass: 256.0801
Molecular Weight: 256.79
Elemental Analysis: C, 56.13; H, 6.67; Cl, 13.80; N, 10.91; S, 12.48
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: HDL376; HDL-376; HDL 376; SDZ HDL376; SDZ-HDL376; SDZHDL376;
IUPAC/Chemical Name: N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea
InChi Key: CVLONJGXRCEARL-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H17ClN2S/c1-8(2)7-14-12(16)15-11-6-10(13)5-4-9(11)3/h4-6,8H,7H2,1-3H3,(H2,14,15,16)
SMILES Code: S=C(NCC(C)C)NC1=CC(Cl)=CC=C1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 256.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nieland TJ, Shaw JT, Jaipuri FA, Maliga Z, Duffner JL, Koehler AN, Krieger M. Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. J Lipid Res. 2007 Aug;48(8):1832-45. Epub 2007 May 28. PubMed PMID: 17533223.
2: Coppola GM, Damon RE, Eskesen JB, France DS, Paterniti JR Jr. Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorg Med Chem Lett. 2006 Jan 1;16(1):113-7. Epub 2005 Oct 10. PubMed PMID: 16216504.
3: Stevens GJ, Hitchcock K, Wang YK, Coppola GM, Versace RW, Chin JA, Shapiro M, Suwanrumpha S, Mangold BL. In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adduct. Chem Res Toxicol. 1997 Jul;10(7):733-41. PubMed PMID: 9250406.
