DABA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581157

CAS#: 38917-80-5

Description: DABA is also known as diaminobenzoic acid. DABA can react with all aldehydes of the form RCH(2)CHO, but deoxyribose is the predominant one in mammalian cells and essentially the only one in the acid or alcohol precipitates of aqueous extracts. Hence, no purification is required and RNA does not interfere. DABA has the high serum stability of the oligomers. for further study dab PNAs as new self-recognizing bio-inspired polymers, it will to be developed new nanomaterials in biotechnological and biomedical applications.


Price and Availability

Size
Price

Size
Price

Size
Price

DABA is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 581157
Name: DABA
CAS#: 38917-80-5
Chemical Formula: C19H24N2O2
Exact Mass: 312.1838
Molecular Weight: 312.41
Elemental Analysis: C, 73.05; H, 7.74; N, 8.97; O, 10.24


Synonym: DABA; diaminobenzoic acid;

IUPAC/Chemical Name: 2-Diethylamino-3'-benzyloxyacetanilide

InChi Key: HXPDIHGLNYYJKU-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H24N2O2/c1-3-21(4-2)14-19(22)20-17-11-8-12-18(13-17)23-15-16-9-6-5-7-10-16/h5-13H,3-4,14-15H2,1-2H3,(H,20,22)

SMILES Code: O=C(NC1=CC=CC(OCC2=CC=CC=C2)=C1)CN(CC)CC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Burrell M, Hanfrey CC, Kinch LN, Elliott KA, Michael AJ. Evolution of a novel lysine decarboxylase in siderophore biosynthesis. Mol Microbiol. 2012 Oct;86(2):485-99. doi: 10.1111/j.1365-2958.2012.08208.x. Epub 2012 Aug 24. PubMed PMID: 22906379.

2: Eilert E, Kranz A, Hollenberg CP, Piontek M, Suckow M. Synthesis and release of the bacterial compatible solute 5-hydroxyectoine in Hansenula polymorpha. J Biotechnol. 2013 Aug 20;167(2):85-93. doi: 10.1016/j.jbiotec.2013.02.005. Epub 2013 Mar 4. PubMed PMID: 23467000.

3: Roviello G, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E. Evidences of complex formation between DABA-based nucleo-gamma-peptides with alternate configuration backbone. J Pept Sci. 2009 Mar;15(3):147-54. doi: 10.1002/psc.1071. PubMed PMID: 19003980.

4: Small SA, Werker JF. Does the ACC have potential as an index of early speech discrimination ability? A preliminary study in 4-month-old infants with normal hearing. Ear Hear. 2012 Nov-Dec;33(6):e59-69. doi: 10.1097/AUD.0b013e31825f29be. PubMed PMID: 22785572.

5: Yamamoto S, Mutoh N, Tsuzuki D, Ikai H, Nakao H, Shinoda S, Narimatsu S, Miyoshi SI. Cloning and characterization of the ddc homolog encoding L-2,4-diaminobutyrate decarboxylase in Enterobacter aerogenes. Biol Pharm Bull. 2000 May;23(5):649-53. PubMed PMID: 10823682.

6: Al-Sammak MA, Hoagland KD, Snow DD, Cassada D. Methods for simultaneous detection of the cyanotoxins BMAA, DABA, and anatoxin-a in environmental samples. Toxicon. 2013 Dec 15;76:316-25. doi: 10.1016/j.toxicon.2013.10.015. Epub 2013 Oct 16. PubMed PMID: 24140919.

7: Al-Sammak MA, Hoagland KD, Cassada D, Snow DD. Co-occurrence of the cyanotoxins BMAA, DABA and anatoxin-a in Nebraska reservoirs, fish, and aquatic plants. Toxins (Basel). 2014 Jan 28;6(2):488-508. doi: 10.3390/toxins6020488. PubMed PMID: 24476710; PubMed Central PMCID: PMC3942747.

8: Gurney T Jr, Gurney EG. DABA Fluorescence Assay for Submicrogram Amounts of DNA. Methods Mol Biol. 1985;2:5-11. doi: 10.1385/0-89603-064-4:5. PubMed PMID: 21374166.

9: He CX, Du PY, Yu XD, Luo TH, Wu J, Zhao CY, Zhou HZ. [Species diversity of ground-dwelling beetles on northern slope of Daba Mountain, China]. Ying Yong Sheng Tai Xue Bao. 2009 Jun;20(6):1459-64. Chinese. PubMed PMID: 19795659.

10: Roskoski R Jr. Comparison of DABA and GABA transport into plasma membrane vesicles derived from synaptosomes. J Neurochem. 1981 Feb;36(2):544-50. PubMed PMID: 6162006.

11: Kushto GP, Jagodzinski PW. Vibrational spectra and normal coordinate analysis of 4-(dimethylamino)benzaldehyde and selected isotopic derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 1998 Jun;54A(6):799-819. PubMed PMID: 9666574.

12: Chen WY, Chen YC. Reducing the alkali cation adductions of oligonucleotides using sol-gel-assisted laser desorption/ionization mass spectrometry. Anal Chem. 2003 Aug 15;75(16):4223-8. PubMed PMID: 14632139.

13: Peng Y, Hu Z, Gao Y, Yuan D, Kang Z, Qian Y, Yan N, Zhao D. Synthesis of a Sulfonated Two-Dimensional Covalent Organic Framework as an Efficient Solid Acid Catalyst for Biobased Chemical Conversion. ChemSusChem. 2015 Oct 12;8(19):3208-12. doi: 10.1002/cssc.201500755. Epub 2015 Sep 3. PubMed PMID: 26448524.

14: Ono H, Sawada K, Khunajakr N, Tao T, Yamamoto M, Hiramoto M, Shinmyo A, Takano M, Murooka Y. Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata. J Bacteriol. 1999 Jan;181(1):91-9. PubMed PMID: 9864317; PubMed Central PMCID: PMC103536.

15: Neal MJ, Cunningham JR, Marshall J. The uptake and radioautographical localization in the frog retina of [3H](+/-)-aminocyclohexane carboxylic acid, a selective inhibitor of neuronal GABA transport. Brain Res. 1979 Nov 2;176(2):285-96. PubMed PMID: 91406.

16: Panasci L, McQuillan A, Feindel W. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21(2):143-4. PubMed PMID: 3349563.

17: Beckmann J, Holze S, Lenzen S, Panten U. Quantification of cells in islets of Langerhans using DNA determination. Acta Diabetol Lat. 1981;18(1):51-7. PubMed PMID: 7010857.

18: Taberner PV, Roberts F. The anticonvulsant action of L-2,4-diaminobutyric acid. Eur J Pharmacol. 1978 Dec 1;52(3-4):281-6. PubMed PMID: 729640.

19: Davies JA, Williams J. A role for 5-hydroxytryptamine in the GABA-mimetic potentiation of alpha-flupenthixol-induced catalepsy in the rat. Br J Pharmacol. 1983 Jan;78(1):137-42. PubMed PMID: 6681721; PubMed Central PMCID: PMC2044774.

20: Reshetnikov AS, Khmelenina VN, Mustakhimov II, Trotsenko YA. Genes and enzymes of ectoine biosynthesis in halotolerant methanotrophs. Methods Enzymol. 2011;495:15-30. doi: 10.1016/B978-0-12-386905-0.00002-4. Review. PubMed PMID: 21419912.