UC-112 | CAS#383392-66-3 | IAP inhibitor

UC-112
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562355

CAS#: 383392-66-3

Description: UC-112 is an IAP inhibitor. It acts by suppressing X-linked inhibitor of apoptosis protein (XIAP) and survivin levels, inhibiting the growth of P-glycoproteins, and activating caspase-3/7 and caspase-9.

Chemical Structure

UC-112

CAS# 383392-66-3

Instruction

Theoretical Analysis

MedKoo Cat#: 562355
Name: UC-112
CAS#: 383392-66-3
Chemical Formula: C22H24N2O2
Exact Mass: 348.18
Molecular Weight: 348.440
Elemental Analysis: C, 75.83; H, 6.94; N, 8.04; O, 9.18

Price and Availability

Size	Price	Availability
10mg	USD 385	2 Weeks
50mg	USD 1315	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: UC-112; UC 112; UC112;

IUPAC/Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol

InChi Key: LTGLGIQQZXSLLF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24N2O2/c25-22-18(14-24-11-4-5-12-24)13-19(20-9-6-10-23-21(20)22)16-26-15-17-7-2-1-3-8-17/h1-3,6-10,13,25H,4-5,11-12,14-16H2

SMILES Code: OC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 348.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. Eur J Med Chem. 2018 Apr 10;149:211-224. doi: 10.1016/j.ejmech.2018.02.045. Epub 2018 Feb 19. PubMed PMID: 29501942; PubMed Central PMCID: PMC5849576.

2: Xiao M, Wang J, Lin Z, Lu Y, Li Z, White SW, Miller DD, Li W. Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties. PLoS One. 2015 Jun 12;10(6):e0129807. doi: 10.1371/journal.pone.0129807. eCollection 2015. PubMed PMID: 26070194; PubMed Central PMCID: PMC4466525.

3: Wang J, Li W. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349(2):319-29. doi: 10.1124/jpet.113.212019. Epub 2014 Mar 12. PubMed PMID: 24623800; PubMed Central PMCID: PMC3989805.

4: Huang SK, Chiu AW, Pu YS, Huang YK, Chung CJ, Tsai HJ, Yang MH, Chen CJ, Hsueh YM. Arsenic methylation capability, myeloperoxidase and sulfotransferase genetic polymorphisms, and the stage and grade of urothelial carcinoma. Urol Int. 2009;82(2):227-34. doi: 10.1159/000200805. Epub 2009 Mar 19. PubMed PMID: 19322015.

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