Edoxudine hydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584382

CAS#: 15176-29-1

Description: Edoxudine is an antiviral agent that has been found to have good efficacy in vivo experiments on hairless mice infected with herpes simplex virus 1.


Chemical Structure

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Edoxudine hydrate
CAS# 15176-29-1

Theoretical Analysis

MedKoo Cat#: 584382
Name: Edoxudine hydrate
CAS#: 15176-29-1
Chemical Formula: C11H18N2O6
Exact Mass: 256.1059
Molecular Weight: 274.273
Elemental Analysis: C, 48.17; H, 6.62; N, 10.21; O, 35.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Edoxudine; EUdR; Epoxudine; Aedurid; Edoxudine hydrate

IUPAC/Chemical Name: 2'-Deoxy-5-ethyluridine hydrate

InChi Key: HUCHTCYDQCXXAB-FZRXOQNUSA-N

InChi Code: InChI=1S/C11H16N2O5.H2O/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9;/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17);1H2/t7-,8+,9+;/m0./s1

SMILES Code: OC[C@@H]1[C@H](C[C@H](N2C(NC(C(CC)=C2)=O)=O)O1)O.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 274.273 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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8: Lee YW, Giziewicz JB, Knaus EE, Wiebe LI. Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VII. [2-14C]-5-ethyl-1-(2'-deoxy-beta-D-ribofuranosyl)uracil. Int J Appl Radiat Isot. 1984 Nov;35(11):1063-6. PubMed PMID: 6335492.

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10: Cory JG, Halley MC, Jeney A, Lapis K. 5-Hexyl-2'-deoxyuridine blocks the cytotoxic effects of 5-fluorodeoxyuridine or deoxyadenosine in leukemia L1210 cells in culture. Cancer Res. 1990 Aug 1;50(15):4552-6. PubMed PMID: 2142444.

11: Shealy YF, O'Dell CA, Arnett G, Shannon WM. Synthesis and antiviral activity of the carbocyclic analogues of 5-ethyl-2'-deoxyuridine and of 5-ethynyl-2'-deoxyuridine. J Med Chem. 1986 Jan;29(1):79-84. PubMed PMID: 3001308.

12: Kralovánszky J, Katona C, Jeney A, Pandi E, Noordhuis P, Erdélyi-Tóth V, Otvös L, Kovács P, Van der Wilt CL, Peters GJ. 5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil. J Cancer Res Clin Oncol. 1999 Dec;125(12):675-84. PubMed PMID: 10592100.

13: Mucsi I. Combined antiviral effects of flavonoids and 5-ethyl-2'-deoxyuridine on the multiplication of herpesviruses. Acta Virol. 1984 Sep;28(5):395-400. PubMed PMID: 6151353.

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15: Jeney A, Barrie SE, Taylor GA, Newell DR, Harrap KR, Szabolcs A, Lapis K, Otvös L. 5-Ethyl-2'-deoxyuridine: an explanation for its lack of cytotoxic action in vivo. Eur J Cancer Clin Oncol. 1986 May;22(5):557-62. PubMed PMID: 3770027.

16: De Clercq E, Bernaerts R. Specific phosphorylation of 5-ethyl-2'-deoxyuridine by herpes simplex virus-infected cells and incorporation into viral DNA. J Biol Chem. 1987 Nov 5;262(31):14905-11. PubMed PMID: 2822705.

17: Joly JM, Williams WM. High-performance liquid chromatographic analysis of 5-ethylpyrimidines and 5-methylpyrimidines in plasma. J Chromatogr. 1991 Feb 15;563(2):392-9. Erratum in: J Chromatogr 1991 Apr 19;565(1-2):552. PubMed PMID: 1878072.

18: Cheraghali AM, Kumar R, Knaus EE, Wiebe LI. Pharmacokinetics and bioavailability of 5-ethyl-2'-deoxyuridine and its novel (5R,6R)-5-bromo-6-ethoxy-5,6-dihydro prodrugs in mice. Drug Metab Dispos. 1995 Feb;23(2):223-6. PubMed PMID: 7736915.

19: Teh CZ, Sacks SL. Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2. Antimicrob Agents Chemother. 1983 May;23(5):637-40. PubMed PMID: 6307130; PubMed Central PMCID: PMC184779.

20: McClain CR, Sim FJ, Goldman SA. Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells. J Neurosci. 2012 Oct 24;32(43):15066-75. doi: 10.1523/JNEUROSCI.1320-12.2012. PubMed PMID: 23100427; PubMed Central PMCID: PMC3700539.