Fenmetozole

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527815

CAS#: 41473-09-0

Description: Fenmetozole is an antagonist of the actions of ethanol.

Chemical Structure

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Fenmetozole
CAS# 41473-09-0
Instruction

Theoretical Analysis

MedKoo Cat#: 527815
Name: Fenmetozole
CAS#: 41473-09-0
Chemical Formula: C10H10Cl2N2O
Exact Mass: 244.02
Molecular Weight: 245.103
Elemental Analysis: C, 49.00; H, 4.11; Cl, 28.93; N, 11.43; O, 6.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Fenmetozole

IUPAC/Chemical Name: 2-[(3,4-Dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole

InChi Key: FVHAONUKSUFJKN-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H10Cl2N2O/c11-8-2-1-7(5-9(8)12)15-6-10-13-3-4-14-10/h1-2,5H,3-4,6H2,(H,13,14)

SMILES Code: ClC1=CC=C(OCC2=NCCN2)C=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 245.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stillings MR, England CD, Welbourn AP, Smith CF. Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists. J Med Chem. 1986 Sep;29(9):1780-3. PubMed PMID: 2875186.

2: Chang H, Ewert SM, Nagel RL. Identification of 2-imidazolines as anti-sickling agents. Mol Pharmacol. 1983 May;23(3):731-4. PubMed PMID: 6865916.

3: Frye GD, Breese GR. An evaluation of the locomotor stimulating action of ethanol in rats and mice. Psychopharmacology (Berl). 1981;75(4):372-9. PubMed PMID: 6803283.

4: Vogel RA, Frye GD, Koepke KM, Mailman RB, Mueller RA, Breese GR. Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex. Alcohol Clin Exp Res. 1981 Summer;5(3):386-92. PubMed PMID: 6792942.

5: Frye GD, Breese GR, Mailman RB, Vogel RA, Ondrusek MG, Mueller RA. An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function. Psychopharmacology (Berl). 1980;69(2):149-55. PubMed PMID: 6256788.

6: Griffis LC, Bright TP, Cerimele BJ, Forney RB. Combined effects of fenmetozole and ethanol. Clin Pharmacol Ther. 1978 Sep;24(3):350-3. PubMed PMID: 357069.

7: Fink M, Irwin P. Fenmetazole (DH-524): euphoriant classified by cerebral electrometry. Curr Ther Res Clin Exp. 1975 Oct;18(4):590-6. PubMed PMID: 810320.

8: McNamee HB, Mendelson JH, Korn J. Fenmetozole in acute alcholol intoxication in man. Clin Pharmacol Ther. 1975 Jun;17(6):735-7. PubMed PMID: 1095283.