WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 527814
CAS#: 95130-23-7 (HCl)
Description: BCI hydrochloride is an allosteric inhibitor of Dusp6, acting within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding.
MedKoo Cat#: 527814
Name: BCI hydrochloride
CAS#: 95130-23-7 (HCl)
Chemical Formula: C22H24ClNO
Exact Mass: 317.178
Molecular Weight: 353.89
Elemental Analysis: C22H24ClNO
Related CAS #: 15982-84-0 (free base) 95130-23-7 (HCl)
Synonym: BCI hydrochloride
IUPAC/Chemical Name: 2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one hydrochloride
InChi Key: JPATUDRDKCLPTI-CRDKNBMZSA-N
InChi Code: InChI=1S/C22H23NO.ClH/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16;/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2;1H/b20-15-;
SMILES Code: O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C\C4=CC=CC=C4.[H]Cl
1: Wu QN, Liao YF, Lu YX, Wang Y, Lu JH, Zeng ZL, Huang QT, Sheng H, Yun JP, Xie D, Ju HQ, Xu RH. Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance. Cancer Lett. 2018 Jan 1;412:243-255. doi: 10.1016/j.canlet.2017.10.007. Epub 2017 Oct 16. PubMed PMID: 29050982.