GDC-0927 free base

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MedKoo CAT#: 206952

CAS#: 1642297-01-5 (free base)

Description: GDC-0927, also known as SRN-927, is a next-generation oral SERD which appears to have greater potential than GDC-0810 to be a best-in-class SERD molecule. GDC-0927 targets estrogen receptor alpha (ERα), a receptor expressed in more than 70% of breast cancers, making it a popular target for the disease. GDC-0927 appears well-tolerated to date with PK exposure supporting QD dosing, evidence of robust PD target engagement, and encouragement of anti-tumor activity in heavily pretreated patients with advanced or metastatic ER+ BC, including patients with ESR1 mutations.

Chemical Structure

GDC-0927 free base
CAS# 1642297-01-5 (free base)

Theoretical Analysis

MedKoo Cat#: 206952
Name: GDC-0927 free base
CAS#: 1642297-01-5 (free base)
Chemical Formula: C28H28FNO4
Exact Mass: 461.2002
Molecular Weight: 461.53
Elemental Analysis: C, 72.87; H, 6.12; F, 4.12; N, 3.03; O, 13.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1642297-01-5 (free base)   1642297-02-6 (HCl)   1642297-03-7 (HBr)    

Synonym: GDC-0927; GDC 0927; GDC0927; SRN-927; SRN 927; SRN927.

IUPAC/Chemical Name: (2S)-2-(4-{2-[3-(Fluoromethyl)-1-azetidinyl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol


InChi Code: InChI=1S/C28H28FNO4/c1-18-25-14-23(32)7-10-26(25)34-28(27(18)21-3-2-4-22(31)13-21)20-5-8-24(9-6-20)33-12-11-30-16-19(15-29)17-30/h2-10,13-14,19,28,31-32H,11-12,15-17H2,1H3/t28-/m0/s1

SMILES Code: OC1=CC(C(C)=C(C2=CC=CC(O)=C2)[C@H](C3=CC=C(OCCN4CC(CF)C4)C=C3)O5)=C5C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 461.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information

R-isomer CAS#
1642297-53-7 (free base), 1642297-54-8 (HCl), 1642297-55-9 (HBr), 1642297-56-0 (sulfate), 1642297-57-1 (phosphate), 1642297-59-3 (acetate),