GDC-0927 free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206952

CAS#: 1642297-01-5 (free base)

Description: GDC-0927, also known as SRN-927, is a next-generation oral SERD which appears to have greater potential than GDC-0810 to be a best-in-class SERD molecule. GDC-0927 targets estrogen receptor alpha (ERα), a receptor expressed in more than 70% of breast cancers, making it a popular target for the disease. GDC-0927 appears well-tolerated to date with PK exposure supporting QD dosing, evidence of robust PD target engagement, and encouragement of anti-tumor activity in heavily pretreated patients with advanced or metastatic ER+ BC, including patients with ESR1 mutations.


Price and Availability

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GDC-0927 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206952
Name: GDC-0927 free base
CAS#: 1642297-01-5 (free base)
Chemical Formula: C28H28FNO4
Exact Mass: 461.2002
Molecular Weight: 461.53
Elemental Analysis: C, 72.87; H, 6.12; F, 4.12; N, 3.03; O, 13.87


Related CAS #: 1642297-01-5 (free base)   1642297-02-6 (HCl)   1642297-03-7 (HBr)    

Synonym: GDC-0927; GDC 0927; GDC0927; SRN-927; SRN 927; SRN927.

IUPAC/Chemical Name: (2S)-2-(4-{2-[3-(Fluoromethyl)-1-azetidinyl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol

InChi Key: KJAAPZIFCQQQKX-NDEPHWFRSA-N

InChi Code: InChI=1S/C28H28FNO4/c1-18-25-14-23(32)7-10-26(25)34-28(27(18)21-3-2-4-22(31)13-21)20-5-8-24(9-6-20)33-12-11-30-16-19(15-29)17-30/h2-10,13-14,19,28,31-32H,11-12,15-17H2,1H3/t28-/m0/s1

SMILES Code: OC1=CC(C(C)=C(C2=CC=CC(O)=C2)[C@H](C3=CC=C(OCCN4CC(CF)C4)C=C3)O5)=C5C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


Additional Information

R-isomer CAS#
1642297-53-7 (free base), 1642297-54-8 (HCl), 1642297-55-9 (HBr), 1642297-56-0 (sulfate), 1642297-57-1 (phosphate), 1642297-59-3 (acetate),