GW438014 free base
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562315

CAS#: 469861-48-1 (free base)

Description: GW438014A is a selective NPY-Y5 receptor antagonist.

Chemical Structure

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GW438014 free base
CAS# 469861-48-1 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 562315
Name: GW438014 free base
CAS#: 469861-48-1 (free base)
Chemical Formula: C22H19N3O
Exact Mass: 341.15
Molecular Weight: 341.410
Elemental Analysis: C, 77.40; H, 5.61; N, 12.31; O, 4.69

Price and Availability

Size Price Availability Quantity
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 5850 2 Weeks
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Related CAS #: 469861-49-2 (mesylate)   469861-48-1 (free base)    

Synonym: GW438014A; GW-438014-A; GW 438014A; GW438014 free base; GW-438014; GW 438014;

IUPAC/Chemical Name: N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide

InChi Key: CDUDZZGLFOFINU-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H19N3O/c26-21(18-11-5-2-6-12-18)24-22-23-19-13-7-8-14-20(19)25(22)16-15-17-9-3-1-4-10-17/h1-14H,15-16H2,(H,23,24,26)

SMILES Code: O=C(NC1=NC2=CC=CC=C2N1CCC3=CC=CC=C3)C4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 341.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Benmaamar R, Richichi C, Gobbi M, Daniels AJ, Beck-Sickinger AG, Vezzani A. Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul Pept. 2005 Feb 15;125(1-3):79-83. PubMed PMID: 15582717.

2: Daniels AJ, Grizzle MK, Wiard RP, Matthews JE, Heyer D. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002 Jun 15;106(1-3):47-54. PubMed PMID: 12047910.