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MedKoo CAT#: 581142

CAS#: 57404-51-0

Description: DA-11004 is a synthetic, potent NADP-dependent isocitrate dehydrogenase (IDPc) inhibitor where IC50 for IDPc is 1.49 microM. DA-11004 inhibited the fatty acid synthesis in adipose tissues via IDPc inhibition, and it decreased the plasma glucose levels and FFA in HF diet-induced obesity of C57BL/6J mice.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-05-28. Prices are subject to change without notice.

DA-11004 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 581142
Name: DA-11004
CAS#: 57404-51-0
Chemical Formula: C11H9NO2
Exact Mass: 187.0633
Molecular Weight: 187.2
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: 80 Elemental Analysis: C, 70.58; H, 4.85; N, 7.48; O, 17.09

Synonym: DA-11004; DA 11004; DA11004; UNII-48M66E9ER2;

IUPAC/Chemical Name: 1,2-Naphthalenedione, 4-(methylamino)-


InChi Code: InChI=1S/C11H9NO2/c1-12-9-6-10(13)11(14)8-5-3-2-4-7(8)9/h2-6,12H,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Shin CY, Jung MY, Lee IK, Son M, Kim DS, Lim JI, Kim SH, Yoo M, Huh TL, Sohn YT, Kim WB. Anti-diabetic effects of DA-11004, a synthetic IDPc inhibitor in high fat high sucrose diet-fed C57BL/6J mice. Arch Pharm Res. 2004 Jan;27(1):48-52. PubMed PMID: 14969338.

2: O'Dell LE, Parsons LH. Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. J Pharmacol Exp Ther. 2004 Nov;311(2):711-9. Epub 2004 Jun 28. PubMed PMID: 15226384.

3: Lin D, Parsons LH. Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze. Pharmacol Biochem Behav. 2002 Apr;71(4):581-7. PubMed PMID: 11888549.

4: Parsons LH, Koob GF, Weiss F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May;32(2):132-5. PubMed PMID: 10231132.

5: Parsons LH, Weiss F, Koob GF. Serotonin1B receptor stimulation enhances cocaine reinforcement. J Neurosci. 1998 Dec 1;18(23):10078-89. PubMed PMID: 9822762.

6: O'Dell LE, Manzardo AM, Polis I, Stouffer DG, Parsons LH. Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration. J Neurochem. 2006 Dec;99(5):1363-76. PubMed PMID: 17074068.