JH-VIII-49

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407893

CAS#: Unknown

Description: JH-VIII-49 is a potent and selective CDK8 inhibitor.


Chemical Structure

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JH-VIII-49
CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 407893
Name: JH-VIII-49
CAS#: Unknown
Chemical Formula: C30H40N2
Exact Mass: 428.3191
Molecular Weight: 428.664
Elemental Analysis: C, 84.06; H, 9.41; N, 6.54

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JH-VIII-49; JH-VIII49; JH-VIII 49; JHVIII-49; JHVIII49; JHVIII 49;

IUPAC/Chemical Name: (3S,8S,10R,13S,14S,17S)-17-(isoquinolin-7-yl)-N,N,10,13-tetramethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-amine

InChi Key: IWZSHWBGHQBIML-ZGGLMWTQSA-N

InChi Code: InChI=1S/C30H40N2/c1-29-14-11-24(32(3)4)18-23(29)7-8-25-27-10-9-26(30(27,2)15-12-28(25)29)21-6-5-20-13-16-31-19-22(20)17-21/h5-7,13,16-17,19,24-28H,8-12,14-15,18H2,1-4H3/t24-,25-,26+,27-,28?,29-,30+/m0/s1

SMILES Code: C[C@@]12[C@@H](C3=CC4=C(C=C3)C=CN=C4)CC[C@@]1([H])[C@]5([H])CC=C6C[C@@H](N(C)C)CC[C@]6(C)C5CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 428.664 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8
John M. Hatcher, Eric S. Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim and Nathanael S. Gray
Publication Date (Web): March 18, 2018 (Letter)
DOI: 10.1021/acsmedchemlett.8b00011