WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407891

CAS#: 2209085-22-1

Description: JH-XI-10-02 is a potent and selective CDK8 inhibitor. JH-XI-10-02 can recruit the E3 ligase CRL4Cereblon to promote the ubiquitination and proteosomal degradation of CDK8.

Chemical Structure

CAS# 2209085-22-1

Theoretical Analysis

MedKoo Cat#: 407891
Name: JH-XI-10-02
CAS#: 2209085-22-1
Chemical Formula: C53H69N5O9
Exact Mass: 919.5095
Molecular Weight: 920.161
Elemental Analysis: C, 69.18; H, 7.56; N, 7.61; O, 15.65

Price and Availability

Size Price Availability Quantity
5.0mg USD 550.0 2 Weeks
10.0mg USD 970.0 2 Weeks
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Synonym: JH-XI-10-02; JH-XI10-02; JH-XI 10-02; JH-XI-1002; JH-XI1002; JH-XI 1002; JHXI-1002; JHXI1002; JHXI 1002;

IUPAC/Chemical Name: 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N-((3S,17S)-17-(isoquinolin-7-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N-methyl-3,6,9,12-tetraoxapentadecan-15-amide


InChi Code: InChI=1S/C53H69N5O9/c1-52-19-15-38(32-37(52)9-10-39-42-12-11-41(53(42,2)20-16-43(39)52)35-8-7-34-17-21-54-33-36(34)31-35)57(3)47(60)18-23-64-25-27-66-29-30-67-28-26-65-24-22-55-44-6-4-5-40-48(44)51(63)58(50(40)62)45-13-14-46(59)56-49(45)61/h4-8,17,21,31,33,37-39,41-43,45,55H,9-16,18-20,22-30,32H2,1-3H3,(H,56,59,61)/t37?,38-,39?,41+,42?,43?,45?,52?,53?/m0/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 920.161 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8
John M. Hatcher, Eric S. Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim and Nathanael S. Gray
Publication Date (Web): March 18, 2018 (Letter)
DOI: 10.1021/acsmedchemlett.8b00011

Additional Information

CDK8 is a cyclin-dependent kinase that forms part of the mediator complex, a multiprotein assembly comprising up to 30 subunits that regulates gene transcription in multiple contexts including stem cell function, immune response, inflammation, cell adhesion, epithelial to mesenchymal transition, and development.