DA 5018

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581139

CAS#: 174661-97-3

Description: DA 5018 is a capsaicin derivative, it has the antipruritic effect. DA 5018 is also a new non-narcotic analgesic.


Price and Availability

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DA 5018 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581139
Name: DA 5018
CAS#: 174661-97-3
Chemical Formula: C22H31ClN2O3
Exact Mass: 406.2023
Molecular Weight: 406.95
Elemental Analysis: C, 64.93; H, 7.68; Cl, 8.71; N, 6.88; O, 11.79


Synonym: DA 5018; DA-5018; DA5018;UNII-51V6N8BA2P;

IUPAC/Chemical Name: 2-(4-(2-aminoethoxy)-3-methoxyphenyl)-N-(3-(3,4-dimethylphenyl)propyl)acetamide hydrochloride

InChi Key: OUEKLNJUMVZULZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N2O3.ClH/c1-16-6-7-18(13-17(16)2)5-4-11-24-22(25)15-19-8-9-20(27-12-10-23)21(14-19)26-3;/h6-9,13-14H,4-5,10-12,15,23H2,1-3H3,(H,24,25);1H

SMILES Code: NCCOc1ccc(CC(NCCCc2ccc(C)c(C)c2)=O)cc1OC.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kim DH, Ahn BO, Kim SH, Kim WB. Antipruritic effect of DA-5018, a capsaicin derivative, in mice. Arch Pharm Res. 1999 Dec;22(6):549-53. PubMed PMID: 10615858.

2: Kang YS, Kim JM. Permeability of a capsaicin derivative, [14C]DA-5018 to blood-brain barrier corrected with HPLC method. Arch Pharm Res. 1999 Apr;22(2):165-72. PubMed PMID: 10230507.

3: Lee JJ, Shim HJ, Kim SH, Lee SD, Kim WB, Yang J, Lee MG. Pharmacokinetics of a non-narcotic analgesic, DA-5018, in rats. Biopharm Drug Dispos. 1998 Mar;19(2):101-8. PubMed PMID: 9533110.

4: Shim HJ, Lee JJ, Lee SD, Kim WB, Yang J, Kim SH, Lee MG. Stability, blood partition, and protein binding of DA-5018, a new nonnarcotic analgesic. Res Commun Mol Pathol Pharmacol. 1996 Jan;91(1):97-108. PubMed PMID: 8824935.

5: Cha BJ, Lee ED, Kim WB, Chung SJ, Lee MH, Shim CK. Enhanced skin permeation of a new capsaicin derivative (DA-5018) from a binary vehicle system composed of isopropyl myristate and ethoxydiglycol. Arch Pharm Res. 2001 Jun;24(3):224-8. PubMed PMID: 11440082.

6: Shim HJ, Lee JJ, Lee SD, Kim WB, Yang J, Kim SH, Lee MG. Determination of a new non-narcotic analgesic, DA-5018, in plasma, urine and bile by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Feb 21;689(2):422-6. PubMed PMID: 9080332.

7: Park YH, You ES, Kim WB, Lee SS. DA-5018, a novel vanilloid type analgesic. Arch Pharm Res. 1997 Feb;20(1):93-5. PubMed PMID: 18975221.

8: Jung J, Hwang SW, Kwak J, Lee SY, Kang CJ, Kim WB, Kim D, Oh U. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J Neurosci. 1999 Jan 15;19(2):529-38. PubMed PMID: 9880573.

9: Shin JS, Wang MH, Hwang SW, Cho H, Cho SY, Kwon MJ, Lee SY, Oh U. Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists. Neurosci Lett. 2001 Feb 16;299(1-2):135-9. PubMed PMID: 11166956.

10: Pearce LV, Toth A, Ryu H, Kang DW, Choi HK, Jin MK, Lee J, Blumberg PM. Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2008 Apr;377(2):149-57. doi: 10.1007/s00210-007-0258-3. Epub 2008 Feb 8. PubMed PMID: 18259730; PubMed Central PMCID: PMC2931423.

11: Sim JH, Kim YC, Kim SJ, Lee SJ, Suh SH, Jun JY, So I, Kim KW. Capsaicin inhibits the voltage-operated calcium channels intracellularly in the antral circular myocytes of guinea-pig stomach. Life Sci. 2001 Apr 13;68(21):2347-60. PubMed PMID: 11350006.