Z-IETD-FMK
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407888

CAS#: 210344-98-2

Description: MDK4982, also known as Z-IETD-FMK, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B., The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. MDK4982 effectively inhibits influenza virus-induced apoptosis in HeLa cells. MDK4982 also inhibits granzyme B. MDK4982 has CAS#210344-98-2.


Chemical Structure

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Z-IETD-FMK
CAS# 210344-98-2

Theoretical Analysis

MedKoo Cat#: 407888
Name: Z-IETD-FMK
CAS#: 210344-98-2
Chemical Formula: C28H39FN4O11
Exact Mass: 626.2599
Molecular Weight: 626.6354
Elemental Analysis: C, 53.67; H, 6.27; F, 3.03; N, 8.94; O, 28.08

Price and Availability

Size Price Availability Quantity
25.0mg USD 950.0 2 Weeks
50.0mg USD 1650.0 2 Weeks
100.0mg USD 2650.0 2 Weeks
200.0mg USD 4650.0 2 Weeks
500.0mg USD 6650.0 2 Weeks
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Synonym: Z-IE(OMe)TD(OMe)-FMK; Granzyme B Inhibitor III; Z-IETD-FMK; MDK4982; MDK-4982; MDK 4982; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F.

IUPAC/Chemical Name: (5S,8S,11S,14S)-5-((S)-sec-butyl)-8-(2-carboxyethyl)-14-(2-fluoroacetyl)-11-((R)-1-hydroxyethyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid

InChi Key: CTXDBLYOEUERAT-VUVYEONESA-N

InChi Code: InChI=1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1

SMILES Code: O=C(O)C[C@@H](C(CF)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC(OCC1=CC=CC=C1)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 626.6354 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lawrence CP, Chow SC. Suppression of human T cell proliferation by the caspase
inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition
properties. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):103-12. doi:
10.1016/j.taap.2012.09.002. Epub 2012 Sep 12. PubMed PMID: 22982538; PubMed
Central PMCID: PMC3875211.