Acexamic acid
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MedKoo CAT#: 571515

CAS#: 57-08-9

Description: Acexamic acid is wound-healing agent and analgesic composed of plasmutan. Acexamic acid is used to avoid pulmonary fibrosis in adult respiratory distress syndrome, but may cause complications including hypercalcemia and hypernatremia.


Chemical Structure

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Acexamic acid
CAS# 57-08-9

Theoretical Analysis

MedKoo Cat#: 571515
Name: Acexamic acid
CAS#: 57-08-9
Chemical Formula: C8H15NO3
Exact Mass: 173.1052
Molecular Weight: 173.21
Elemental Analysis: C, 55.47; H, 8.73; N, 8.09; O, 27.71

Price and Availability

Size Price Availability Quantity
5.0g USD 250.0 2 Weeks
10.0g USD 450.0 2 Weeks
100.0g USD 750.0 2 Weeks
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Synonym: Acexamic acid; NSC 12945; NSC-12945; NSC12945; Plastenan

IUPAC/Chemical Name: 6-Acetamidohexanoic acid

InChi Key: WDSCBUNMANHPFH-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H15NO3/c1-7(10)9-6-4-2-3-5-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)

SMILES Code: O=C(O)CCCCCNC(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 173.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Reis AM, Silva R, Pignatelli J. Allergic contact dermatitis to acexamic acid. Contact Dermatitis. 2008 Apr;58(4):241-2. doi: 10.1111/j.1600-0536.2007.01258.x. PubMed PMID: 18353035.

2: Bronner G, Litzler A, Conraux C. [Anti-pulmonary fibrosis effect of acexamic acid in bleomycin therapy]. J Fr Otorhinolaryngol Audiophonol Chir Maxillofac. 1980 Sep;29(7):471-8. French. PubMed PMID: 6159453.

3: Daoudal P, Boillot A, Berthout P, Bourgeois F, Barale F. [So-called refractory hypoxemia: treatment with acexamic acid]. Nouv Presse Med. 1979 Dec 3;8(47):3899. French. PubMed PMID: 95046.

4: Guillard O, Masson P, Piriou A, Brugier JC, Courtois P. Comparison of the anti-inflammatory activity of sodium acexamate and zinc acexamate in healing skin wounds in rabbits. Pharmacology. 1987;34(5):296-300. PubMed PMID: 3615571.

5: Torres-Molina F, Martínez-Coscollá A, Gisbert S, Quintana E, Sendrós S, Peris-Ribera JE, Plá-Delfina JM. Kinetics of the intestinal uptake of zinc acexamate in normal and zinc-depleted rats. J Pharm Pharmacol. 1990 Oct;42(10):679-84. PubMed PMID: 1982137.

6: Dănilă G, Ungureanu M, Dorneanu V, Lupaşcu D. [The production of nitro esters active at the level of the cardiovascular system]. Rev Med Chir Soc Med Nat Iasi. 1996 Jul-Dec;100(3-4):227-31. Romanian. PubMed PMID: 9455471.

7: Porte A, Stoeckel ME, Mantz JM, Tempe JD, Jaeger A, Batzenschlager A. Acute interstitial pulmonary fibrosis. Comparative light and electron microscopic study of 19 cases. Pathogenic and therapeutic implications. Intensive Care Med. 1978 Nov;4(4):181-91. PubMed PMID: 739076.

8: Gisbert-González SL, Torres-Molina F. Zinc uptake in five sectors of the rat gastrointestinal tract: kinetic study in the whole colon. Pharm Res. 1996 Aug;13(8):1154-61. PubMed PMID: 8865304.

9: Dănilă G, Rusu G, Ungureanu M, Alexandrescu G. [The production of pharmacologically active acexamic acid derivatives. I. The production of acexamic acid and its zinc salt]. Rev Med Chir Soc Med Nat Iasi. 1990 Apr-Jun;94(2):381-4. Romanian. PubMed PMID: 2100856.

10: Delavierre P, Bourdais JP, Letailleur M, Hureau J, Vayre P, Roux M. [Colonic Crohn's disease: diagnostic and therapeutic problems. Apropos of 11 cases]. Sem Hop. 1976 May 23;52(20):1195-1206. French. PubMed PMID: 189397.

11: Charachon R, Junien-Lavillauroy PC, Serero C, Accoyer B. [Therepeutic study of acexamic acid in tympanoplasty]. Ann Otolaryngol Chir Cervicofac. 1972 Mar;89(3):181-4. French. PubMed PMID: 5052461.