DA 1131

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MedKoo CAT#: 581138

CAS#: 169285-98-7

Description: DA 1131 is a new carbapenem antibiotic, undergoes renal metabolism by renal dehydropeptidase I (DHP-I), located on the brush border of the proximal tubular cell. Species differences with the effects of cilastatin, a renal DHP-I inhibitor, after a 1-min intravenous infusion of DA-1131, with or without cilastatin, to rats, rabbits, and dogs.


Price and Availability

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Pricing updated 2020-06-03. Prices are subject to change without notice.

DA 1131 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581138
Name: DA 1131
CAS#: 169285-98-7
Chemical Formula: C18H27N3O6S2
Exact Mass: 445.1341
Molecular Weight: 445.55
Elemental Analysis: C, 48.52; H, 6.11; N, 9.43; O, 21.55; S, 14.39


Synonym: DA 1131; DA-1131; DA1131;

IUPAC/Chemical Name: (4R,5S)-6-(1-hydroxyethyl)-4-methyl-3-(((3S,5S)-5-((E)-3-(methylsulfonamido)prop-1-en-1-yl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

InChi Key: UXCCOLVNQUBDAJ-FGQVXFQSSA-N

InChi Code: InChI=1S/C18H27N3O6S2/c1-9-14-13(10(2)22)17(23)21(14)15(18(24)25)16(9)28-12-7-11(19-8-12)5-4-6-20-29(3,26)27/h4-5,9-14,19-20,22H,6-8H2,1-3H3,(H,24,25)/b5-4+/t9-,10?,11-,12+,13?,14-/m1/s1

SMILES Code: C[C@@H]1[C@@H]2C(C(=O)N2C(=C1S[C@H]3C[C@H](NC3)/C=C/CNS(=O)(=O)C)C(=O)O)C(C)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kim SH, Kim WB, Lee MG. Effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in rats and rabbits. Antimicrob Agents Chemother. 1999 Jan;43(1):96-9. PubMed PMID: 9869572; PubMed Central PMCID: PMC89027.

2: Kim SH, Shim HJ, Kim WB, Lee MG. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with uranyl nitrate-induced acute renal failure. Antimicrob Agents Chemother. 1998 May;42(5):1217-21. PubMed PMID: 9593153; PubMed Central PMCID: PMC105781.

3: Kim SH, Kwon JW, Lee MG. Pharmacokinetics and tissue distribution of a new carbapenem DA-1131, after intravenous administration to mice, rats, rabbits and dogs. Biopharm Drug Dispos. 1998 May;19(4):219-29. PubMed PMID: 9604121.

4: Kim SH, Kwon JW, Kim WB, Lee MG. Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs. Antimicrob Agents Chemother. 1999 Oct;43(10):2524-7. PubMed PMID: 10508037; PubMed Central PMCID: PMC89513.

5: Kim SH, Kim WB, Lee MG. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with alloxan-induced diabetes mellitus. Biopharm Drug Dispos. 1998 Jul;19(5):303-8. PubMed PMID: 9673782.

6: Park SW, We JS, Kim GW, Choi SH, Park HS. Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I). Antimicrob Agents Chemother. 2002 Feb;46(2):575-7. PubMed PMID: 11796382; PubMed Central PMCID: PMC127065.

7: Kim SH, Kim WB, Kwon JW, Lee MG. Nephroprotective effect of betamipron on a new carbapenem, DA-1131, in rabbits. Biopharm Drug Dispos. 1999 Apr;20(3):125-9. PubMed PMID: 10211864.

8: Kim SH, Kim WB, Lee MG. No effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in dogs. Res Commun Mol Pathol Pharmacol. 1998 Jul;101(1):85-92. PubMed PMID: 9755846.

9: Kim SH, Kwon JW, Kim WB, Lee I, Lee MG. Effects of water deprivation for 72 hours on the pharmacokinetics of a new carbapenem, DA-1131, in rats. Life Sci. 2002 Sep 27;71(19):2291-8. PubMed PMID: 12215376.

10: Kim SH, Kim WB, Lee MG. Interspecies pharmacokinetic scaling of a new carbapenem, DA-1131, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics. Biopharm Drug Dispos. 1998 May;19(4):231-5. PubMed PMID: 9604122.

11: Kim SH, Kim WB, Lee MG. Pharmacokinetic changes of a new carbapenem, DA-1131, after intravenous administration to spontaneously hypertensive rats and deoxycorticosterone acetate-salt-induced hypertensive rats. Drug Metab Dispos. 1999 Jun;27(6):710-6. PubMed PMID: 10348801.

12: Lee ED, Lee SD, Kim WB, Yang J, Kim SH, Lee MG. Determination of a new carbapenem antibiotic, DA-1131, in rat plasma, urine, and bile by column-switching high-performance liquid chromatography. Res Commun Mol Pathol Pharmacol. 1996 Nov;94(2):171-80. PubMed PMID: 8987114.

13: Kim SH, Kim WB, Lee MG. Stability, tissue metabolism, tissue distribution, and blood partition of DA-1131, a new carbapenem. Res Commun Mol Pathol Pharmacol. 1995 Dec;90(3):347-62. PubMed PMID: 8746482.

14: Kim SH, Kwon JW, Yang J, Lee MG. Determination of a new carbapenem derivative, DA-1131, in plasma and urine by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Jan 10;688(1):95-9. PubMed PMID: 9029318.