WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562297

CAS#: 280571-30-4

Description: S-1360 is a HIV-1 integrase inhibitor.

Chemical Structure

CAS# 280571-30-4

Theoretical Analysis

MedKoo Cat#: 562297
Name: S-1360
CAS#: 280571-30-4
Chemical Formula: C16H12FN3O3
Exact Mass: 313.09
Molecular Weight: 313.280
Elemental Analysis: C, 61.34; H, 3.86; F, 6.06; N, 13.41; O, 15.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: S-1360; S 1360; S1360; GSK-S-1360; GW810781; GW-810781; GW 810781; GSKS1360; GSK S 1360;

IUPAC/Chemical Name: (Z)-1-[5-[(4-Fluorophenyl)methyl]furan-2-yl]-3-hydroxy-3-(1H-1,2,4-triazol-5-yl)prop-2-en-1-one


InChi Code: InChI=1S/C16H12FN3O3/c17-11-3-1-10(2-4-11)7-12-5-6-15(23-12)13(21)8-14(22)16-18-9-19-20-16/h1-6,8-9,22H,7H2,(H,18,19,20)/b14-8-

SMILES Code: O=C(C1=CC=C(CC2=CC=C(F)C=C2)O1)/C=C(O)/C3=NC=NN3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 313.280000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kashyap T, Germain E, Roche M, Lyle S, Rabinovitz I. Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. Lab Invest. 2011 Oct;91(10):1414-26. doi: 10.1038/labinvest.2011.104. Epub 2011 Jul 18. PubMed PMID: 21769085; PubMed Central PMCID: PMC3184203. 2: Huang M, Grant GH, Richards WG. Binding modes of diketo-acid inhibitors of HIV-1 integrase: a comparative molecular dynamics simulation study. J Mol Graph Model. 2011 Jun;29(7):956-64. doi: 10.1016/j.jmgm.2011.04.002. Epub 2011 Apr 9. PubMed PMID: 21531158; PubMed Central PMCID: PMC3101338. 3: Bacchi A, Carcelli M, Compari C, Fisicaro E, Pala N, Rispoli G, Rogolino D, Sanchez TW, Sechi M, Neamati N. HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding. Mol Pharm. 2011 Apr 4;8(2):507-19. doi: 10.1021/mp100343x. Epub 2011 Mar 8. PubMed PMID: 21323359. 4: Barreca ML, Iraci N, De Luca L, Chimirri A. 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Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. Antimicrob Agents Chemother. 2008 Jun;52(6):2069-78. doi: 10.1128/AAC.00911-07. Epub 2008 Mar 31. PubMed PMID: 18378713; PubMed Central PMCID: PMC2415791. 10: Dayam R, Al-Mawsawi LQ, Neamati N. Substituted 2-pyrrolinone inhibitors of HIV-1 integrase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6155-9. Epub 2007 Sep 20. PubMed PMID: 17911021. 11: Alves CN, Martí S, Castillo R, Andrés J, Moliner V, Tuñón I, Silla E. A quantum mechanics/molecular mechanics study of the protein-ligand interaction for inhibitors of HIV-1 integrase. Chemistry. 2007;13(27):7715-24. PubMed PMID: 17570717. 12: Nair V, Chi G. HIV integrase inhibitors as therapeutic agents in AIDS. Rev Med Virol. 2007 Jul-Aug;17(4):277-95. Review. PubMed PMID: 17503547. 13: Dayam R, Al-Mawsawi LQ, Neamati N. HIV-1 integrase inhibitors: an emerging clinical reality. 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