DA 4643

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581136

CAS#: 95833-19-5

Description: DA 4643 is one of histamine H2-receptor antagonistic. Two histamine H2-receptor antagonists of the phenylformamidine type, mifentidine (N-isopropyl-N'-(4-1H-imidazol-4-yl-phenyl) formamidine dihydrochloride; I) and DA 4643 (N-methyl-N'-(3-(2-guanidinothiazol-4-yl)-phenyl) formamidine dihydrochloride; II), have been investigated by experimental physico-chemical studies and theoretical conformational analysis. Both mifentidine and DA 4643 interact with the histamine H2-receptor at the same site, utilizing in the binding process the same, or closely similar, receptor structural features.


Price and Availability

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DA 4643 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581136
Name: DA 4643
CAS#: 95833-19-5
Chemical Formula: C12H14N6S
Exact Mass: 274.1001
Molecular Weight: 274.35
Elemental Analysis: C, 52.54; H, 5.14; N, 30.63; S, 11.69


Synonym: DA 4643; DA-4643; DA4643;

IUPAC/Chemical Name: N-Methyl-N'-(3-(2-guanidinothiazol-4-yl)phenyl)formamidine

InChi Key: MRTUBNJTWHQTJJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14N6S/c1-15-7-16-9-4-2-3-8(5-9)10-6-19-12(17-10)18-11(13)14/h2-7H,1H3,(H,15,16)(H4,13,14,17,18)

SMILES Code: N=C(N)NC1=NC(C2=CC(/N=C/NC)=CC=C2)=CS1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Donetti A, Trummlitz G, Bietti G, Cereda E, Bazzano C, Wagner HU. Conformational studies of two histamine H2-receptor antagonistic phenylformamidines: mifentidine and its guanidinothiazole analogue DA 4643. Arzneimittelforschung. 1985;35(1A):306-15. PubMed PMID: 2859031.

2: Paquay JB, Bolscher MT, Voss HP, Timmerman H, Bast A. Difference in the inhibition of nitric oxide synthase and cytochrome P-450 by some H(2)-antagonists. Toxicol In Vitro. 1997 Dec;11(6):775-8. PubMed PMID: 20654383.