DA 4643

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581136

CAS#: 95833-19-5

Description: DA 4643 is one of histamine H2-receptor antagonistic. Two histamine H2-receptor antagonists of the phenylformamidine type, mifentidine (N-isopropyl-N'-(4-1H-imidazol-4-yl-phenyl) formamidine dihydrochloride; I) and DA 4643 (N-methyl-N'-(3-(2-guanidinothiazol-4-yl)-phenyl) formamidine dihydrochloride; II), have been investigated by experimental physico-chemical studies and theoretical conformational analysis. Both mifentidine and DA 4643 interact with the histamine H2-receptor at the same site, utilizing in the binding process the same, or closely similar, receptor structural features.

Price and Availability




DA 4643 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 581136
Name: DA 4643
CAS#: 95833-19-5
Chemical Formula: C12H14N6S
Exact Mass: 274.1001
Molecular Weight: 274.35
Elemental Analysis: C, 52.54; H, 5.14; N, 30.63; S, 11.69

Synonym: DA 4643; DA-4643; DA4643;

IUPAC/Chemical Name: N-Methyl-N'-(3-(2-guanidinothiazol-4-yl)phenyl)formamidine


InChi Code: InChI=1S/C12H14N6S/c1-15-7-16-9-4-2-3-8(5-9)10-6-19-12(17-10)18-11(13)14/h2-7H,1H3,(H,15,16)(H4,13,14,17,18)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Donetti A, Trummlitz G, Bietti G, Cereda E, Bazzano C, Wagner HU. Conformational studies of two histamine H2-receptor antagonistic phenylformamidines: mifentidine and its guanidinothiazole analogue DA 4643. Arzneimittelforschung. 1985;35(1A):306-15. PubMed PMID: 2859031.

2: Paquay JB, Bolscher MT, Voss HP, Timmerman H, Bast A. Difference in the inhibition of nitric oxide synthase and cytochrome P-450 by some H(2)-antagonists. Toxicol In Vitro. 1997 Dec;11(6):775-8. PubMed PMID: 20654383.