Josamycin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341150

CAS#: 16846-24-5

Description: Josamycin is a macrolide antibiotic.


Chemical Structure

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Josamycin
CAS# 16846-24-5

Theoretical Analysis

MedKoo Cat#: 341150
Name: Josamycin
CAS#: 16846-24-5
Chemical Formula: C42H69NO15
Exact Mass: 827.4667
Molecular Weight: 828.006
Elemental Analysis: C, 60.92; H, 8.40; N, 1.69; O, 28.98

Price and Availability

Size Price Availability Quantity
100.0mg USD 255.0 2 Weeks
250.0mg USD 465.0 2 Weeks
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Synonym: Josamycin; CCRIS 8511

IUPAC/Chemical Name: Leucomycin V, 3-acetate 4(sup B)-(3-methylbutanoate)

InChi Key: XJSFLOJWULLJQS-DJBGMQKKSA-N

InChi Code: InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12-,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1

SMILES Code: O([C@@H]1[C@H]([C@@H](CC(O[C@@H](CC=CC=C[C@@H]([C@@H](C[C@@H]1CC=O)C)O)C)=O)OC(C)=O)OC)[C@H]1[C@@H]([C@H]([C@H](O[C@H]2C[C@@]([C@@H](OC(CC(C)C)=O)[C@@H](O2)C)(C)O)[C@H](O1)C)N(C)C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 828.006 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhou YH, Ma HX, Yang Y, Gu WM. Prevalence and antimicrobial resistance of Ureaplasma spp. and Mycoplasma hominis isolated from semen samples of infertile men in Shanghai, China from 2011 to 2016. Eur J Clin Microbiol Infect Dis. 2018 Jan 8. doi: 10.1007/s10096-017-3167-5. [Epub ahead of print] PubMed PMID: 29313203.

2: Loreto ES, Tondolo JSM, Oliveira DC, Santurio JM, Alves SH. In Vitro Activities of Miltefosine and Antibacterial Agents from the Macrolide, Oxazolidinone, and Pleuromutilin Classes against Pythium insidiosum and Pythium aphanidermatum. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01678-17. doi: 10.1128/AAC.01678-17. Print 2018 Mar. PubMed PMID: 29311087.

3: Maraki S, Mavromanolaki VE, Nioti E, Stafylaki D, Minadakis G. Prevalence and antimicrobial susceptibility of Ureaplasma species and Mycoplasma hominis in Greek female outpatients, 2012-2016. J Chemother. 2017 Nov 28:1-5. doi: 10.1080/1120009X.2017.1404287. [Epub ahead of print] PubMed PMID: 29182058.

4: Kasprzykowska U, Sobieszczańska B, Duda-Madej A, Secewicz A, Nowicka J, Gościniak G. A twelve-year retrospective analysis of prevalence and antimicrobial susceptibility patterns of Ureaplasma spp. and Mycoplasma hominis in the province of Lower Silesia in Poland. Eur J Obstet Gynecol Reprod Biol. 2018 Jan;220:44-49. doi: 10.1016/j.ejogrb.2017.11.010. Epub 2017 Nov 14. PubMed PMID: 29154180.

5: Zhang X, Li J, Wang C, Song D, Hu C. Identification of impurities in macrolides by liquid chromatography-mass spectrometric detection and prediction of retention times of impurities by constructing quantitative structure-retention relationship (QSRR). J Pharm Biomed Anal. 2017 Oct 25;145:262-272. doi: 10.1016/j.jpba.2017.06.069. Epub 2017 Jul 6. PubMed PMID: 28700970.

6: Arsic B, Barber J, Čikoš A, Mladenovic M, Stankovic N, Novak P. 16-membered macrolide antibiotics: a review. Int J Antimicrob Agents. 2018 Mar;51(3):283-298. doi: 10.1016/j.ijantimicag.2017.05.020. Epub 2017 Jun 28. Review. PubMed PMID: 28668674.

7: Matsui K, Tachioka K, Onodera K, Ikeda R. Topical Application of Josamycin Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. J Pharm Pharm Sci. 2017;20:38-47. doi: 10.18433/J3GW3D. PubMed PMID: 28459659.

8: Zhao ZH, Jin LL, Xu YP, Liu C, Wang AP, Lei PS. Synthesis and antibacterial activities of some novel 17, 18-unsaturated carbonyl compounds derivated from josamycin. J Asian Nat Prod Res. 2017 Apr;19(4):358-387. doi: 10.1080/10286020.2016.1194834. Epub 2016 Sep 26. PubMed PMID: 28276768.

9: Komiya K, Ohta S, Arima K, Ogawa M, Suzuki S, Mitamura Y, Nunomura S, Nanri Y, Yoshihara T, Kawaguchi A, Kadota JI, Rubin BK, Izuhara K. Clarithromycin attenuates IL-13-induced periostin production in human lung fibroblasts. Respir Res. 2017 Feb 20;18(1):37. doi: 10.1186/s12931-017-0519-8. PubMed PMID: 28219384; PubMed Central PMCID: PMC5319114.

10: Matsui K, Tamai S, Ikeda R. Effects of Macrolide Antibiotics on Th1 Cell and Th2 Cell Development Mediated by Langerhans Cells. J Pharm Pharm Sci. 2016 Jul - Sep;19(3):357-366. doi: 10.18433/J3Z32F. PubMed PMID: 27806249.

11: Jensen JS, Cusini M, Gomberg M, Moi H. 2016 European guideline on Mycoplasma genitalium infections. J Eur Acad Dermatol Venereol. 2016 Oct;30(10):1650-1656. doi: 10.1111/jdv.13849. Epub 2016 Aug 9. Review. PubMed PMID: 27505296.

12: Kong Y, Qiao Y, Song J, Ruan Z, Fei C, Huang J, Song T, Jin H, Ding H, Xie X, Zhang J. Comparative analysis of male and female populations on prevalence and antibiotic resistance of Mycoplasma hominis in China, 2005-2014. J Glob Antimicrob Resist. 2016 Sep;6:69-72. doi: 10.1016/j.jgar.2016.03.004. Epub 2016 Apr 30. PubMed PMID: 27530842.

13: Zeng XY, Xin N, Tong XN, Wang JY, Liu ZW. Prevalence and antibiotic susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in Xi'an, China. Eur J Clin Microbiol Infect Dis. 2016 Dec;35(12):1941-1947. Epub 2016 Aug 16. PubMed PMID: 27530531.

14: Zhu X, Li M, Cao H, Yang X, Zhang C. Epidemiology of Ureaplasma urealyticum and Mycoplasma hominis in the semen of male outpatients with reproductive disorders. Exp Ther Med. 2016 Aug;12(2):1165-1170. Epub 2016 May 31. PubMed PMID: 27443698; PubMed Central PMCID: PMC4950889.

15: He M, Xie Y, Zhang R, Gao S, Xu G, Zhang L, Liu P, Li Y, Wu S. Prevalence and antimicrobial resistance of Mycoplasmas and Chlamydiae in patients with genital tract infections in Shanghai, China. J Infect Chemother. 2016 Aug;22(8):548-52. doi: 10.1016/j.jiac.2016.05.007. Epub 2016 Jun 17. PubMed PMID: 27324895.

16: Saigal K, Dhawan B, Rawre J, Khanna N, Chaudhry R. Genital Mycoplasma and Chlamydia trachomatis infections in patients with genital tract infections attending a tertiary care hospital of North India. Indian J Pathol Microbiol. 2016 Apr-Jun;59(2):194-6. doi: 10.4103/0377-4929.182019. PubMed PMID: 27166039.

17: Wei J, Shen A, Yan J, Jin G, Yang B, Guo Z, Zhang F, Liang X. Separation analysis of macrolide antibiotics with good performance on a positively charged C18HCE column. J Sep Sci. 2016 Mar;39(6):1073-81. doi: 10.1002/jssc.201500923. Epub 2016 Feb 24. PubMed PMID: 26782089.

18: Abrogoua DP, Koffi NO, Doffou E. [Pharmacist interventions on antibiotic prescriptions in outpatient pediatric unit in a teaching hospital of Côte d'Ivoire]. Ann Pharm Fr. 2016 Sep;74(5):380-8. doi: 10.1016/j.pharma.2015.12.004. Epub 2016 Jan 13. French. PubMed PMID: 26774460.

19: Azizmohammadi S, Azizmohammadi S. Antimicrobial Susceptibility Patterns of Ureaplasma urealyticum and Mycoplasma hominis Isolated From Pregnant Women. Iran Red Crescent Med J. 2015 Dec 28;17(12):e17211. doi: 10.5812/ircmj.17211. eCollection 2015 Dec. Retraction in: Iran Red Crescent Med J. 2016 Mar 03;18(3):e43586. PubMed PMID: 26756001; PubMed Central PMCID: PMC4707011.

20: Berthe-Aucejo A, Girard D, Lorrot M, Bellettre X, Faye A, Mercier JC, Brion F, Bourdon O, Prot-Labarthe S. Evaluation of frequency of paediatric oral liquid medication dosing errors by caregivers: amoxicillin and josamycin. Arch Dis Child. 2016 Apr;101(4):359-64. doi: 10.1136/archdischild-2015-309426. Epub 2016 Jan 4. PubMed PMID: 26729746.

Josamycin

100.0mg / USD 255.0