WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581134
Description: DA 4626 is H2-receptor antagonism. The compounds which were investigated in a wider concentration range, i.e. DA 4360, DA 4577, and DA 4626, behaved as simple competitive antagonists, yielding apparent KB values comparable with those estimated in conventional H2-receptor assays. These results provide further evidence for the highly selective H2-receptor antagonism of these new molecules, and confirm the suitability of the histamine-stimulated adenylate cyclase assay in guinea-pig gastric cells as a functionally reduced system for the study of H2 antagonists.
MedKoo Cat#: 581134
Name: DA 4626
Chemical Formula: C14H18N4
Exact Mass: 242.1531
Molecular Weight: 242.33
Elemental Analysis: C, 69.39; H, 7.49; N, 23.12
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Synonym: DA 4626; DA-4626; DA4626;
IUPAC/Chemical Name: (E)-N'-(4-(1H-imidazol-4-yl)phenyl)-N-(tert-butyl)formimidamide
InChi Key: KUEHILWIADUSSA-UHFFFAOYSA-N
InChi Code: 1S/C14H18N4/c1-14(2,3)18-10-16-12-6-4-11(5-7-12)13-8-15-9-17-13/h4-10H,1-3H3,(H,15,17)(H,16,18)
SMILES Code: CC(C)(C)N/C=N/c1ccc(cc1)c2c[nH]cn2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 242.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Micheletti R, Oliva D, Belfiore P, Giachetti A, Nicosia S. Evaluation of novel compounds interacting with H2-histamine receptors: effect on histamine-sensitive adenylate cyclase activity in guinea-pig gastric mucosa. Agents Actions. 1985 Jul;16(5):291-4. PubMed PMID: 2864816.