WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581134
Description: DA 4626 is H2-receptor antagonism. The compounds which were investigated in a wider concentration range, i.e. DA 4360, DA 4577, and DA 4626, behaved as simple competitive antagonists, yielding apparent KB values comparable with those estimated in conventional H2-receptor assays. These results provide further evidence for the highly selective H2-receptor antagonism of these new molecules, and confirm the suitability of the histamine-stimulated adenylate cyclase assay in guinea-pig gastric cells as a functionally reduced system for the study of H2 antagonists.
MedKoo Cat#: 581134
Name: DA 4626
Chemical Formula: C14H18N4
Exact Mass: 242.1531
Molecular Weight: 242.33
Elemental Analysis: C, 69.39; H, 7.49; N, 23.12
Synonym: DA 4626; DA-4626; DA4626;
IUPAC/Chemical Name: (E)-N'-(4-(1H-imidazol-4-yl)phenyl)-N-(tert-butyl)formimidamide
InChi Key: KUEHILWIADUSSA-UHFFFAOYSA-N
InChi Code: 1S/C14H18N4/c1-14(2,3)18-10-16-12-6-4-11(5-7-12)13-8-15-9-17-13/h4-10H,1-3H3,(H,15,17)(H,16,18)
SMILES Code: CC(C)(C)N/C=N/c1ccc(cc1)c2c[nH]cn2
1: Micheletti R, Oliva D, Belfiore P, Giachetti A, Nicosia S. Evaluation of novel compounds interacting with H2-histamine receptors: effect on histamine-sensitive adenylate cyclase activity in guinea-pig gastric mucosa. Agents Actions. 1985 Jul;16(5):291-4. PubMed PMID: 2864816.