VXN20903
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527787

CAS#: 332420-90-3

Description: VXN20903, also known as TNFalpha-IN-C87 or C87, is a TNF-alpha inhibitor, inhibiting TNF-alpha-induced cytotoxicity in L929 fibroblast cells. VXN20903 has CAS#332420-90-3, was first reported in J.Biol.Chem. 2014, 289 12457. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).


Chemical Structure

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VXN20903
CAS# 332420-90-3

Theoretical Analysis

MedKoo Cat#: 527787
Name: VXN20903
CAS#: 332420-90-3
Chemical Formula: C24H15ClN6O3S
Exact Mass: 502.06
Molecular Weight: 502.933
Elemental Analysis: C, 57.32; H, 3.01; Cl, 7.05; N, 16.71; O, 9.54; S, 6.37

Price and Availability

Size Price Availability Quantity
10mg USD 325
50mg USD 1250
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Synonym: TNFalpha-IN-C87, VXN20903; VXN-20903; VXN 20903; C87.

IUPAC/Chemical Name: 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]

InChi Key: VELQTEBILFDDQX-XAYXJRQQSA-N

InChi Code: InChI=1S/C24H15ClN6O3S/c25-18-12-11-17(13-20(18)31(33)34)27-28-22-21(16-9-5-2-6-10-16)29-30(23(22)32)24-26-19(14-35-24)15-7-3-1-4-8-15/h1-14,27H/b28-22+

SMILES Code: O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C4=CC=CC=C4)C3=N\NC5=CC=C(Cl)C([N+]([O-])=O)=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 502.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Ma et al (2014) A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 289 12457 PMID: 24634219