BBMP

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527775

CAS#: 97120-13-3

Description: BBMP is a mitochondrial permeability transition pore (PTP) inhibitor.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-25. Prices are subject to change without notice.

BBMP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 527775
Name: BBMP
CAS#: 97120-13-3
Chemical Formula: C12H11BrN2O3S
Exact Mass: 341.9674
Molecular Weight: 343.195
Elemental Analysis: C, 42.00; H, 3.23; Br, 23.28; N, 8.16; O, 13.99; S, 9.34


Synonym: BBMP

IUPAC/Chemical Name: 5-Benzylsulfonyl-4-bromo-2-methylpyridazin-3-one

InChi Key: ICJYBAMRYLSLQT-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H11BrN2O3S/c1-15-12(16)11(13)10(7-14-15)19(17,18)8-9-5-3-2-4-6-9/h2-7H,8H2,1H3

SMILES Code: O=C1C(Br)=C(S(=O)(CC2=CC=CC=C2)=O)C=NN1C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Gilde F, Fourel L, Guillot R, Pignot-Paintrand I, Okada T, Fitzpatrick V, Boudou T, Albiges-Rizo C, Picart C. Stiffness-dependent cellular internalization of matrix-bound BMP-2 and its relation to Smad and non-Smad signaling. Acta Biomater. 2016 Dec;46:55-67. doi: 10.1016/j.actbio.2016.09.014. Epub 2016 Sep 12. PubMed PMID: 27633320; PubMed Central PMCID: PMC5113753.

2: Kayano AM, Simões-Silva R, Medeiros PS, Maltarollo VG, Honorio KM, Oliveira E, Albericio F, da Silva SL, Aguiar AC, Krettli AU, Fernandes CF, Zuliani JP, Calderon LA, Stábeli RG, Soares AM. BbMP-1, a new metalloproteinase isolated from Bothrops brazili snake venom with in vitro antiplasmodial properties. Toxicon. 2015 Nov;106:30-41. doi: 10.1016/j.toxicon.2015.09.005. Epub 2015 Sep 10. PubMed PMID: 26363289.

3: Zhang J, Chen SG, Habaerxi K, Alimujiang S, Chen Y, Peng MZ, Yue R, Wu YL, Wang DQ, Chen YM. Reinforcing effect of calcium sulfate cement bovine bone morphogenetic protein on vertebral in the rabbit model of osteoporosis. Asian Pac J Trop Med. 2014 May;7(5):382-5. doi: 10.1016/S1995-7645(14)60060-2. PubMed PMID: 25063065.

4: Chethana T, Thapsey H, Gautham MS, Sreekantaiah P, Suryanarayana SP. Situation analysis and issues in management of biomedical waste in select small health care facilities in a ward under Bruhat Bengaluru Mahanagara Palike, Bangalore, India. J Community Health. 2014 Apr;39(2):310-5. doi: 10.1007/s10900-013-9761-2. PubMed PMID: 23982773.

5: Shetty V, Sanil D, Shetty NJ. Insecticide susceptibility status in three medically important species of mosquitoes, Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus, from Bruhat Bengaluru Mahanagara Palike, Karnataka, India. Pest Manag Sci. 2013 Feb;69(2):257-67. doi: 10.1002/ps.3383. Epub 2012 Aug 27. PubMed PMID: 22926921.

6: Guo L, Huang J, Zheng LM. Bifunctional bacterial magnetic nanoparticles for tumor targeting. Nanoscale. 2012 Feb 7;4(3):879-84. doi: 10.1039/c2nr11407k. Epub 2012 Jan 4. PubMed PMID: 22218728.

7: Sepioł J, Grabowska A, Borowicz P, Kijak M, Broquier M, Jouvet Ch, Dedonder-Lardeux C, Zehnacker-Rentien A. Excited-state intramolecular proton transfer reaction modulated by low-frequency vibrations: an effect of an electron-donating substituent on the dually fluorescent bis-benzoxazole. J Chem Phys. 2011 Jul 21;135(3):034307. doi: 10.1063/1.3609759. PubMed PMID: 21787003.

8: Pan W, Wei Y, Zhou L, Li D. Comparative in vivo study of injectable biomaterials combined with BMP for enhancing tendon graft osteointegration for anterior cruciate ligament reconstruction. J Orthop Res. 2011 Jul;29(7):1015-21. doi: 10.1002/jor.21351. Epub 2011 Feb 9. PubMed PMID: 21308754.

9: Zoń J, Kong D, Gagnon K, Perry H, Holliness L, Clearfield A. Supramolecular networks of polymethylphosphonic acid groups bonded to aromatic platforms: biphenyldiyl-2,2'-bis(methylphosphonic acid) and benzenetriyl-1,3,5-tris(methylphosphonic acid). Dalton Trans. 2010 Dec 7;39(45):11008-18. doi: 10.1039/c0dt00676a. Epub 2010 Oct 20. PubMed PMID: 20963215.

10: Casado PL, Duarte ME, Carvalho W, Esmeraldo da Silva L, Barboza EP. Ridge bone maintenance in human after extraction. Implant Dent. 2010 Aug;19(4):314-22. doi: 10.1097/ID.0b013e3181dec322. PubMed PMID: 20683288.

11: Adli M, Garipagaoglu M, Kocak Z. Effect of bladder distention on bladder base dose in gynaecological intracavitary high dose rate brachytherapy. Br J Radiol. 2009 Mar;82(975):243-8. doi: 10.1259/bjr/90233932. Epub 2008 Dec 8. PubMed PMID: 19064593.

12: Ma X, Hu Y, Wu X, Yan Y, Xiong Z, Lu R, Wang J, Li D, Xu X. [Surface modification of biodegradable polymer/TCP scaffolds and related research]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Jun;25(3):571-7. Chinese. PubMed PMID: 18693433.

13: Wu ZX, Wei L, Hu YY, Wang HQ, Wan SY, Wang J, Han Y. Staged-injection procedure to prevent cement leakage during vertebroplasty: an in vitro study. Spine (Phila Pa 1976). 2007 Oct 15;32(22):2437-42. PubMed PMID: 18090082.

14: Lima AF, Rahal SC, Volpi Rdos S, Granjeiro JM, Taga R, Cestari TM. Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits. Acta Cir Bras. 2007 Jul-Aug;22(4):260-5. PubMed PMID: 17625663.

15: Luzina E, Sepioł J, Svartsov YN, Grabowska A. Effect of alkyl substituents on excited state intramolecular proton transfer dynamics of jet-cooled bis(benzoxazolyl)phenoles. J Chem Phys. 2007 May 21;126(19):194308. PubMed PMID: 17523805.

16: Bi L, Hu Y, Fan H, Meng G, Liu J, Li D, Lv R. Treatment of contaminated bone defects with clindamycin-reconstituted bone xenograft-composites. J Biomed Mater Res B Appl Biomater. 2007 Aug;82(2):418-27. PubMed PMID: 17330892.

17: Sun L, Hu YY, Xiong Z, Wang WM, Pan Y. Repair of the radial defect of rabbit with polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology. Chin J Traumatol. 2006 Oct;9(5):298-302. PubMed PMID: 17026863.

18: Serra E Silva FM, Ricardo de Albergaria-Barbosa J, Mazzonetto R. Clinical evaluation of association of bovine organic osseous matrix and bovine bone morphogenetic protein versus autogenous bone graft in sinus floor augmentation. J Oral Maxillofac Surg. 2006 Jun;64(6):931-5. PubMed PMID: 16713808.

19: Fuks B, Talaga P, Huart C, Hénichart JP, Bertrand K, Grimée R, Lorent G. In vitro properties of 5-(benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone: a novel permeability transition pore inhibitor. Eur J Pharmacol. 2005 Sep 5;519(1-2):24-30. PubMed PMID: 16099453.

20: Sun L, Hu YY, Xiong Z, Wang WM, Pan Y. [Repair of the radial defect of rabbit by polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology]. Zhonghua Wai Ke Za Zhi. 2005 Apr 15;43(8):535-9. Chinese. PubMed PMID: 15938915.