WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584372
Description: E 0747 is an antiarrhythmic agent of class 1C type of the Vaughan Williams' classification. E-0747 suppresses arrhythmia by inhibiting Na channels of cardiac cells and is expected to become a clinically useful antiarrhythmic drug.
MedKoo Cat#: 584372
Name: E 0747
Chemical Formula: C21H28ClN3O4
Exact Mass: 421.1768
Molecular Weight: 421.922
Elemental Analysis: C, 59.78; H, 6.69; Cl, 8.40; N, 9.96; O, 15.17
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: E 0747; E0747; E-0747
IUPAC/Chemical Name: Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 2,3-dihydro-6-chloro-2,2-dimethyl-1'-(3-(4-hydroxy-1-piperidinyl)propyl)-
InChi Key: VDDQRGRMFUGJDD-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H28ClN3O4/c1-20(2)13-21(16-12-14(22)4-5-17(16)29-20)18(27)25(19(28)23-21)9-3-8-24-10-6-15(26)7-11-24/h4-5,12,15,26H,3,6-11,13H2,1-2H3,(H,23,28)
SMILES Code: O=C1NC2(C(N1CCCN3CCC(O)CC3)=O)CC(C)(C)OC4=CC=C(Cl)C=C24
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 421.922 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Mitsuhashi H, Akiyama K, Hashimoto K, Sawa Y, Hatori Y. Antiarrhythmic effects of a new drug, E-0747, on canine ventricular arrhythmia models. Jpn J Pharmacol. 1987 Jun;44(2):155-62. PubMed PMID: 3656773.
2: Sawada K, Shoji T, Igarashi T, Hiraoka M. Voltage- and rate-dependent depression of Vmax of action potentials by a new antiarrhythmic agent, E-0747, in swine cardiac Purkinje fibers. J Cardiovasc Pharmacol. 1987 Jan;9(1):51-6. PubMed PMID: 2434794.
3: Hamamoto T, Kojima M, Matsuzaki M, Kusukawa R, Ban T. A model study of time- and voltage-dependent effects of class I antiarrhythmic drugs in guinea-pig papillary muscles as related to external potassium concentration. Arzneimittelforschung. 1994 Aug;44(8):929-37. PubMed PMID: 7945535.