WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555187
CAS#: 144707-18-6
Description: 2-D08 is a synthetic flavone that inhibits sumoylation. 2-D08 showed anti-aggregatory and neuroprotective effect
MedKoo Cat#: 555187
Name: 2-D08
CAS#: 144707-18-6
Chemical Formula: C15H10O5
Exact Mass: 270.0528
Molecular Weight: 270.24
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60
Synonym: 2-D08; 2D08; 2 D08.
IUPAC/Chemical Name: 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one
InChi Key: JJAXTFSPCLZPIW-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H10O5/c16-10-6-5-9(14(18)15(10)19)13-7-11(17)8-3-1-2-4-12(8)20-13/h1-7,16,18-19H
SMILES Code: O=C1C=C(C2=CC=C(O)C(O)=C2O)OC3=CC=CC=C13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 270.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Baik H, Boulanger M, Hosseini M, Kowalczyk J, Zaghdoudi S, Salem T, Sarry JE, Hicheri Y, Cartron G, Piechaczyk M, Bossis G. Targeting the SUMO pathway primes all-trans retinoic acid-induced differentiation of non-promyelocytic acute myeloid leukemias. Cancer Res. 2018 Feb 27. pii: canres.3361.2017. doi: 10.1158/0008-5472.CAN-17-3361. [Epub ahead of print] PubMed PMID: 29487199.
2: Yu F, Wang L, Wang H, Sheng J, Lu L. Repression of SUMOylation pathway by grass carp reovirus contributes to the upregulation of PKR in an IFN-independent manner. Oncotarget. 2017 Aug 17;8(42):71500-71511. doi: 10.18632/oncotarget.20309. eCollection 2017 Sep 22. PubMed PMID: 29069722; PubMed Central PMCID: PMC5641065.
3: Marsh DT, Das S, Ridell J, Smid SD. Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08). Bioorg Med Chem. 2017 Jul 15;25(14):3827-3834. doi: 10.1016/j.bmc.2017.05.041. Epub 2017 May 19. PubMed PMID: 28559058.
4: Kim YS, Keyser SG, Schneekloth JS Jr. Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7. doi: 10.1016/j.bmcl.2014.01.010. Epub 2014 Jan 11. PubMed PMID: 24468414; PubMed Central PMCID: PMC3970184.
