WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584369
Description: D 2343 is a Beta 2-adrenoreceptor agonist with alpha 1-adrenoreceptor blocking properties. This compound has 5-6 times lower potency than terbutaline, but has a longer bronchodilating effect.
MedKoo Cat#: 584369
Name: D 2343
Chemical Formula: C20H27NO3
Exact Mass: 329.1991
Molecular Weight: 329.44
Elemental Analysis: C, 72.92; H, 8.26; N, 4.25; O, 14.57
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: D 2343; D2343; D-2343
IUPAC/Chemical Name: Benzenemethanol, 4-hydroxy-alpha-(((3-(2-methoxyphenyl)-1,1-dimethylpropyl)amino)methyl)-
InChi Key: QQNHGKXYJUREIZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H27NO3/c1-20(2,13-12-16-6-4-5-7-19(16)24-3)21-14-18(23)15-8-10-17(22)11-9-15/h4-11,18,21-23H,12-14H2,1-3H3
SMILES Code: OC(CNC(C)(C)CCC1=CC=CC=C1OC)C2=CC=C(O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 329.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Löfdahl CG, Bengtsson B, Svedmyr K, Svedmyr N. Two new beta 2-adrenoceptor agonists, D-2343 and QH 25, studied in asthmatic patients. Allergy. 1982 Jul;37(5):351-7. PubMed PMID: 6127039.
2: Löfdahl CG, Svedmyr N. Selectivity of beta-adrenergic stimulating and blocking agents. Eur J Respir Dis Suppl. 1984;136:101-13. PubMed PMID: 6145618.
3: Löfdahl CG, Svedmyr K, Svedmyr N, Andersson P, Bengtsson B, Olsson OA, Waldeck B. Comparison of beta 2-adrenoceptor stimulation in bronchial and skeletal muscle in experimental and clinical studies. Eur J Respir Dis Suppl. 1984;135:124-7. PubMed PMID: 6329798.
4: Olsson OA, Gustafsson B. The effect of D2343 in transmurally stimulated rabbit isthmus muscle. Acta Pharmacol Toxicol (Copenh). 1985 May;56(5):427-30. PubMed PMID: 2863921.
5: Löfdahl CG, Svedmyr N. A new beta 2-adrenoceptor agonist--D 2343--with long duration. Inhalation comparison with terbutaline in asthmatics. Allergy. 1984 Aug;39(6):485-9. PubMed PMID: 6437263.
6: Olsson OA, Ahlquist B, Gustafsson B. A new beta 2-adrenoceptor agonist with alpha 1-adrenoceptor blocking properties. Acta Pharmacol Toxicol (Copenh). 1981 Apr;48(4):340-8. PubMed PMID: 6121453.
7: Ingemarsson I, Arulkumaran S, Chua S. Effects of D2343, a new beta-mimetic drug, and terbutaline on spontaneous term labor. Gynecol Obstet Invest. 1988;26(2):130-5. PubMed PMID: 3146531.
8: Olsson OA, Ahlquist B, Gustafsson B, Persson G. The effects in myometrial preparations of D2343, a beta 2-adrenoceptor agonist possessing alpha 1-receptor blocking qualities. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):391-7. PubMed PMID: 6152105.