ML-792
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407886

CAS#: 1644342-14-2

Description: ML-792 is a potent and selective SAE inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. Moreover, Induction of the MYC oncogene increased the ML-792-mediated viability effect in cancer cells, thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors. ML-792 provides rapid loss of endogenously SUMOylated proteins, thereby facilitating novel insights into SUMO biology.


Price and Availability

Size
Price

5mg
USD 250
50mg
USD 1450
Size
Price

10mg
USD 450
100mg
USD 2450
Size
Price

25mg
USD 850
200mg
USD 4250

ML-792, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407886
Name: ML-792
CAS#: 1644342-14-2
Chemical Formula: C21H23BrN6O5S
Exact Mass: 550.0634
Molecular Weight: 551.416
Elemental Analysis: C, 45.74; H, 4.20; Br, 14.49; N, 15.24; O, 14.51; S, 5.81


Synonym: ML-792; ML 792; ML792.

IUPAC/Chemical Name: ((1R,2S,4R)-4-((5-(1-(3-bromobenzyl)-1H-pyrazole-3-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate

InChi Key: PZCKLTWSXFDLLP-OGWOLHLISA-N

InChi Code: InChI=1S/C21H23BrN6O5S/c22-15-3-1-2-13(6-15)10-28-5-4-18(27-28)20(30)17-9-24-12-25-21(17)26-16-7-14(19(29)8-16)11-33-34(23,31)32/h1-6,9,12,14,16,19,29H,7-8,10-11H2,(H2,23,31,32)(H,24,25,26)/t14-,16-,19+/m1/s1

SMILES Code: O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=NN(CC4=CC=CC(Br)=C4)C=C3)=O)C1)(N)=O


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, Bernard H, Yang
X, Liao H, Rabino C, Shah P, Xega K, Yan ZH, Sintchak M, Bradley J, Xu H, Duffey
M, England D, Mizutani H, Hu Z, Guo J, Chau R, Dick LR, Brownell JE, Newcomb J,
Langston S, Lightcap ES, Bence N, Pulukuri SM. Probing the roles of SUMOylation
in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017
Nov;13(11):1164-1171. doi: 10.1038/nchembio.2463. Epub 2017 Sep 11. PubMed PMID:
28892090.