WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562225

CAS#: 2411853-34-2

Description: JR-AB2-011 is a potent and selective inhibitor of mTORC2 kinase activity. It markedly reduces mTORC2 signaling and IC50 while enhancing apoptotic levels in GBM cells. Note: JR-AB2-011 when published, the structure was CAS#329182-61-8. The same author corrected the structure in https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212160. The new structure has CAS#2411853-34-2

Chemical Structure

CAS# 2411853-34-2

Theoretical Analysis

MedKoo Cat#: 562225
Name: JR-AB2-011
CAS#: 2411853-34-2
Chemical Formula: C17H14Cl2FN3OS
Exact Mass: 397.0219
Molecular Weight: 398.27
Elemental Analysis: C, 51.27; H, 3.54; Cl, 17.80; F, 4.77; N, 10.55; O, 4.02; S, 8.05

Price and Availability

Size Price Availability Quantity
5.0mg USD 450.0 2 Weeks
10.0mg USD 750.0 2 Weeks
50.0mg USD 1850.0 2 Weeks
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Related CAS #: 2411853-34-2   329182-61-8 (wrong)    

Synonym: JR-AB2-011; JR AB-2-011; jb-AB 2-011; JRAB2011; JRAB-2011; JRAB 2011;

IUPAC/Chemical Name: (Z)-N-(3,4-dichlorophenyl)-2-((4-fluorophenyl)imino)-5-methylthiazolidine-3-carboxamide


InChi Code: InChI=1S/C17H14Cl2FN3OS/c1-10-9-21-17(25-10)23(13-5-2-11(20)3-6-13)16(24)22-12-4-7-14(18)15(19)8-12/h2-8,10H,9H2,1H3,(H,22,24)

SMILES Code: ClC1=C(Cl)C=C(NC(N2/C(SC(C)C2)=N/C3=CC=C(F)C=C3)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 398.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Benavides-Serrato A, Lee J, Holmes B, Landon KA, Bashir T, Jung ME, Lichtenstein A, Gera J. Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma. PLoS One. 2017 Apr 28;12(4):e0176599. doi: 10.1371/journal.pone.0176599. eCollection 2017. PubMed PMID: 28453552; PubMed Central PMCID: PMC5409528.

Additional Information