WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584357
Description: Namirotene is a synthetic retinoic acid analog seen to be effective in the treatment of keratoconjunctivitis sicca (KCS) in rabbit.
MedKoo Cat#: 584357
Chemical Formula: C17H18O2S
Exact Mass: 286.1028
Molecular Weight: 286.389
Elemental Analysis: C, 71.30; H, 6.34; O, 11.17; S, 11.19
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Namirotene; CBS 211A; Cbs 211 A
IUPAC/Chemical Name: Benzoic acid, 4-(2-(5-(1-methylethyl)-2-thienyl)-1-propenyl)-, (E)-
InChi Key: GDDUESKGWJTHLR-ZRDIBKRKSA-N
InChi Code: InChI=1S/C17H18O2S/c1-11(2)15-8-9-16(20-15)12(3)10-13-4-6-14(7-5-13)17(18)19/h4-11H,1-3H3,(H,18,19)/b12-10+
SMILES Code: O=C(O)C1=CC=C(/C=C(C2=CC=C(C(C)C)S2)\C)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 286.389 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Taimi M, Defacque H, Commes T, Favero J, Dornand J, Marti J. The retinoic acid analog CBS-211A potentiates the 1 alpha,25-dihydroxyvitamin D3-induced differentiation of U937 cells. Agents Actions. 1993 Jan;38(1-2):91-9. PubMed PMID: 8480542.
2: Driot JY, Bonne C. Beneficial effects of a retinoic acid analog, CBS-211 A, on an experimental model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 1992 Jan;33(1):190-5. PubMed PMID: 1730541.
3: Roussillon S, Bonne C, Coquelet C, Tournoux A. Quantitative parameters of a high-affinity binding site for retinoic acid in corneal endothelial cells. Cornea. 1986;5(3):145-9. PubMed PMID: 2980830.
4: Bonne C, Junquero D, Driot JY, Coquelet C, Modat G. [Effect of retinoids on the growth of corneal endothelial cells in culture]. Ophtalmologie. 1990 Jan-Feb;4(1):84-7. French. PubMed PMID: 2250947.
5: Junquéro D, Modat G, Coquelet C, Bonne C. Retinoid-induced potentiation of epidermal growth factor mitogenic effect on corneal endothelial cells. Cornea. 1990 Jan;9(1):41-4. PubMed PMID: 2297993.
6: Junquéro D, Modat G, Coquelet C, Bonne C. Retinoids enhance the number of EGF receptors in corneal endothelial cells. Exp Eye Res. 1990 Jul;51(1):49-53. PubMed PMID: 2373180.