Vitacoxib

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MedKoo CAT#: 562212

CAS#: 1374128-90-1

Description: Vitacoxib is a selective COX-2 inhibitor that is used as a novel nonsteroidal anti-inflammatory agent.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-08-11. Prices are subject to change without notice.

Vitacoxib is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562212
Name: Vitacoxib
CAS#: 1374128-90-1
Chemical Formula: C16H14ClN3O2S
Exact Mass: 347.0495
Molecular Weight: 347.81
Elemental Analysis: C, 55.25; H, 4.06; Cl, 10.19; N, 12.08; O, 9.20; S, 9.22


Synonym: Vitacoxib;

IUPAC/Chemical Name: 2-(4-Chloro-5-(p-tolyl)-1H-imidazol-1-yl)-5-(methylsulfonyl)pyridine

InChi Key: NSWKPXFHCORWAE-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14ClN3O2S/c1-11-3-5-12(6-4-11)15-16(17)19-10-20(15)14-8-7-13(9-18-14)23(2,21)22/h3-10H,1-2H3

SMILES Code: O=S(C1=CN=C(N2C(C3=CC=C(C)C=C3)=C(Cl)N=C2)C=C1)(C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Wang J, Li Z, Sun F, Tang S, Zhang S, Lv P, Li J, Cao X. Evaluation of dermal irritation and skin sensitization due to vitacoxib. Toxicol Rep. 2017 Jun 10;4:287-290. doi: 10.1016/j.toxrep.2017.06.003. eCollection 2017. PubMed PMID: 28959651; PubMed Central PMCID: PMC5615138.

2: Wang J, Zhao T, Kong J, Peng H, Lv P, Li J, Cao X, Zhang S. Determination of vitacoxib, a novel COX-2 inhibitor, in equine plasma using UPLC-MS/MS detection: Development and validation of new methodology. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:270-274. doi: 10.1016/j.jchromb.2017.07.024. Epub 2017 Jul 15. PubMed PMID: 28759842.

3: Wang J, Sun F, Tang S, Zhang S, Lv P, Li J, Cao X. Safety assessment of vitacoxib: Acute and 90-day sub-chronic oral toxicity studies. Regul Toxicol Pharmacol. 2017 Jun;86:49-58. doi: 10.1016/j.yrtph.2017.02.020. Epub 2017 Feb 24. PubMed PMID: 28238853.