WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562209

CAS#: 1042735-18-1

Description: ABC1183 is a selective dual GSK3α/β and CKD9 inhibitor.

Chemical Structure

CAS# 1042735-18-1

Theoretical Analysis

MedKoo Cat#: 562209
Name: ABC1183
CAS#: 1042735-18-1
Chemical Formula: C18H14N4OS
Exact Mass: 334.0888
Molecular Weight: 334.39
Elemental Analysis: C, 64.65; H, 4.22; N, 16.75; O, 4.78; S, 9.59

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
25.0mg USD 750.0 2 Weeks
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Synonym: ABC1183; ABC-1183; ABC 1183;

IUPAC/Chemical Name: 4-(4-Amino-2-p-tolylamino-thiazole-5-carbonyl)-benzonitrile


InChi Code: InChI=1S/C18H14N4OS/c1-11-2-8-14(9-3-11)21-18-22-17(20)16(24-18)15(23)13-6-4-12(10-19)5-7-13/h2-9H,20H2,1H3,(H,21,22)

SMILES Code: N#CC1=CC=C(C(C2=C(N)N=C(NC3=CC=C(C)C=C3)S2)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 334.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Schrecengost RS, Green CL, Zhuang Y, Keller SN, Smith RA, Maines LW, Smith CD. In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183. J Pharmacol Exp Ther. 2018 Apr;365(1):107-116. doi: 10.1124/jpet.117.245738. Epub 2018 Feb 6. PubMed PMID: 29434052.


5.0mg / USD 250.0