TPX-0005
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407885

CAS#: 1802220-02-5

Description: TPX-0005 is a Src/FAK/Janus kinase 2 (JAK2) inhibitor. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing.


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 1950
5g
USD 7650
Size
Price

100mg
USD 650
1g
USD 3250
Size
Price

200mg
USD 1150
2g
USD 5750

TPX-0005, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407885
Name: TPX-0005
CAS#: 1802220-02-5
Chemical Formula: C18H18FN5O2
Exact Mass: 355.1445
Molecular Weight: 355.3734
Elemental Analysis: C, 60.84; H, 5.11; F, 5.35; N, 19.71; O, 9.00


Synonym: TPX-0005; TPX 0005; TPX0005.

IUPAC/Chemical Name: (7S,13R)-11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one

InChi Key: FIKPXCOQUIZNHB-WDEREUQCSA-N

InChi Code: InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1

SMILES Code: O=C1NC[C@H](C)OC2=CC=C(F)C=C2[C@@H](C)NC3=NC4=C1C=NN4C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Karachaliou N, Chaib I, Cardona AF, Berenguer J, Bracht JWP, Yang J, Cai X,
Wang Z, Hu C, Drozdowskyj A, Servat CC, Servat JC, Ito M, Attili I, Aldeguer E,
Capitan AG, Rodriguez J, Rojas L, Viteri S, Molina-Vila MA, Ou SI, Okada M, Mok
TS, Bivona TG, Ono M, Cui J, Cajal SRY, Cao P, Rosell R. Common Co-activation of
AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With
Poor Prognosis. EBioMedicine. 2018 Feb 5. pii: S2352-3964(18)30050-1. doi:
10.1016/j.ebiom.2018.02.001. [Epub ahead of print] PubMed PMID: 29433983.