Bauerenol
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581100

CAS#: 6466-94-0

Description: Bauerenol is a triterpenoid from Indian Suregada angustifolia, is isolated from the stem bark of Acronychia pedunculata., Induces reactive oxygen species-mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma (HepG2) cells. Bauerenol is an Antitrypanosomal Agent.


Chemical Structure

img
Bauerenol
CAS# 6466-94-0

Theoretical Analysis

MedKoo Cat#: 581100
Name: Bauerenol
CAS#: 6466-94-0
Chemical Formula: C30H50O
Exact Mass: 426.729
Molecular Weight: 426.3862
Elemental Analysis: C, 84.44; H, 11.81; O, 3.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Bauerenol; Baurenol; EINECS 229-283-0; NSC 147745;

IUPAC/Chemical Name: (3R,4aR,6bR,8aR,11R,12S,12aR,12bR,14aR,14bR)-4,4,6b,8a,11,12,12b,14b-octamethyl-1,2,3,4,4a,5,6b,7,8,8a,9,10,11,12,12a,12b,13,14,14a,14b-icosahydropicen-3-ol

InChi Key: TZVDWGXUGGUMCE-WXRCDFDUSA-N

InChi Code: InChI=1S/C30H50O/c1-19-11-14-27(5)17-18-29(7)22-9-10-23-26(3,4)24(31)13-15-28(23,6)21(22)12-16-30(29,8)25(27)20(19)2/h9,19-21,23-25,31H,10-18H2,1-8H3/t19-,20+,21+,23+,24-,25-,27-,28-,29+,30-/m1/s1

SMILES Code: C[C@@]12CC[C@](CC[C@@H](C)[C@@H]3C)(C)[C@@H]3[C@@]1(C)CC[C@@H]4[C@](CC[C@H](C5(C)C)O)(C)[C@H]5CC=C42

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 426.3862 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Li JJ, Wang AL, Yuan ZZ, Wu CY, Yang LH, Shang XY. [Triterpene compounds of Ainsliaea yunnanensis]. Zhongguo Zhong Yao Za Zhi. 2013 Nov;38(22):3918-22. Chinese. PubMed PMID: 24558876.

2: Sathish Kumar P, Viswanathan MBG, Venkatesan M, Balakrishna K. Bauerenol, a triterpenoid from Indian Suregada angustifolia: Induces reactive oxygen species-mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma (HepG2) cells. Tumour Biol. 2017 Apr;39(4):1010428317698387. doi: 10.1177/1010428317698387. PubMed PMID: 28443465.

3: Ragasa CY, Espineli DL, Agoo EM, Del Fierro RS. Chemical constituents of Cinnamomum cebuense. Chin J Nat Med. 2013 May;11(3):264-8. doi: 10.1016/S1875-5364(13)60026-6. PubMed PMID: 23725839.

4: Anyanwu GO, Nisar-ur-Rehman, Onyeneke CE, Rauf K. Medicinal plants of the genus Anthocleista--A review of their ethnobotany, phytochemistry and pharmacology. J Ethnopharmacol. 2015 Dec 4;175:648-67. doi: 10.1016/j.jep.2015.09.032. Epub 2015 Nov 11. Review. PubMed PMID: 26432351.

5: Shi HM, Long BS, Cui XM, Min ZD. A new bisabolane sesquiterpenoid from Euphorbia chrysocoma. J Asian Nat Prod Res. 2005 Dec;7(6):857-60. PubMed PMID: 16308205.

6: Raga DD, Herrera AA, Ragasa CY. Angio-suppressive triterpenoids from Ardisia cf. elliptica (subgenus Tinus) on duck (Anas platyrynchos L.) chorioallantoic membrane. Chin J Nat Med. 2013 Mar;11(2):128-38. doi: 10.1016/S1875-5364(13)60039-4. PubMed PMID: 23787179.

7: Deng Y, Lu CY, Guo DL, Mei L. [Studies on the chemical constituents of Ardisia tenera]. Zhong Yao Cai. 2011 Mar;34(3):380-3. Chinese. PubMed PMID: 21823453.

8: Zhou FX, Min ZD. [Studies on the chemical constituents of Acronychia pedunculata (L.) Mig]. Zhongguo Zhong Yao Za Zhi. 1989 Feb;14(2):30-1, 62. Chinese. PubMed PMID: 2506892.

9: Fang XP, Wang TZ, Zhang H, Shuai H, Li D, Xie CK. [Quantitative determination of 5 alkaloids in plants of Coptis from China]. Zhongguo Zhong Yao Za Zhi. 1989 Feb;14(2):33-5, 63. Chinese. PubMed PMID: 2506894.

10: Yu KY, Wu W, Li SZ, Dou LL, Liu LL, Li P, Liu EH. A new compound, methylbergenin along with eight known compounds with cytotoxicity and anti-inflammatory activity from Ardisia japonica. Nat Prod Res. 2017 Nov;31(22):2581-2586. doi: 10.1080/14786419.2017.1283495. Epub 2017 Jan 30. PubMed PMID: 28135873.

11: Carothers S, Nyamwihura R, Collins J, Zhang H, Park H, Setzer WN, Ogungbe IV. Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent. Molecules. 2018 Feb 8;23(2). pii: E355. doi: 10.3390/molecules23020355. PubMed PMID: 29419735.