Benamocaine

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341120

CAS#: 39787-47-8

Description: Benamocaine is a biochemical.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-08-10. Prices are subject to change without notice.

Benamocaine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 341120
Name: Benamocaine
CAS#: 39787-47-8
Chemical Formula: C19H21NO2
Exact Mass: 295.1572
Molecular Weight: 295.382
Elemental Analysis: C, 77.26; H, 7.17; N, 4.74; O, 10.83


Synonym: Benamocaine; YAU-17

IUPAC/Chemical Name: 1-Naphthalenol, 2-(dimethylamino)-1,2,3,4-tetrahydro-, benzoate (ester), cis-

InChi Key: LBQGJHNNGUZLOH-MSOLQXFVSA-N

InChi Code: InChI=1S/C19H21NO2/c1-20(2)17-13-12-14-8-6-7-11-16(14)18(17)22-19(21)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-,18+/m1/s1

SMILES Code: CN(C)[C@@H]1CCc2ccccc2[C@@H]1OC(=O)c3ccccc3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ljubojević Hadžavdić S, Gojčeta Burnić S, Hadžavdić A, Marinović Kulišić S, Jurakić Tončić R. Erythema of the penis after use of a latex condom - latex allergy or something else? Contact Dermatitis. 2018 Feb;78(2):168-169. doi: 10.1111/cod.12879. PubMed PMID: 29341187.

2: Mangiapia G, Gvaramia M, Kuhrts L, Teixeira J, Koutsioubas A, Soltwedel O, Frielinghaus H. Effect of benzocaine and propranolol on phospholipid-based bilayers. Phys Chem Chem Phys. 2017 Dec 6;19(47):32057-32071. doi: 10.1039/c7cp06077g. PubMed PMID: 29181470.

3: Ip EJ, Patel PB, Chi JJ, Shah-Manek B, Lau B. What are pharmacists recommending for infant teething treatment? J Am Pharm Assoc (2003). 2018 Jan - Feb;58(1):79-83.e1. doi: 10.1016/j.japh.2017.10.009. Epub 2017 Nov 15. PubMed PMID: 29153854.

4: da Silva EB, da Silva Corrêa SA, de Souza Abessa DM, da Silva BFX, Rivero DHRF, Seriani R. Mucociliary transport, differential white blood cells, and cyto-genotoxicity in peripheral erythrocytes in fish from a polluted urban pond. Environ Sci Pollut Res Int. 2018 Jan;25(3):2683-2690. doi: 10.1007/s11356-017-0729-0. Epub 2017 Nov 13. PubMed PMID: 29134526.

5: Kaufman MR, Aouad RK. Benzocaine-Induced Methemoglobinemia. J Emerg Med. 2017 Dec;53(6):912-913. doi: 10.1016/j.jemermed.2017.09.004. Epub 2017 Nov 6. PubMed PMID: 29102098.

6: Gibbs S, Kosten I, Veldhuizen R, Spiekstra S, Corsini E, Roggen E, Rustemeyer T, Feilzer AJ, Kleverlaan CJ. Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay. Toxicology. 2018 Jan 15;393:62-72. doi: 10.1016/j.tox.2017.10.014. Epub 2017 Oct 25. PubMed PMID: 29079364.

7: Thygesen MM, Rasmussen MM, Madsen JG, Pedersen M, Lauridsen H. Propofol (2,6-diisopropylphenol) is an applicable immersion anesthetic in the axolotl with potential uses in hemodynamic and neurophysiological experiments. Regeneration (Oxf). 2017 Jul 27;4(3):124-131. doi: 10.1002/reg2.80. eCollection 2017 Jun. PubMed PMID: 28975032; PubMed Central PMCID: PMC5617899.

8: Wang S, Giannakopoulos H, Lowstetter J, Kaye L, Lee C, Secreto S, Ho V, Hutcheson MC, Farrar JT, Wang P, Doyle G, Cooper SA, Hersh EV. Lack of Methemoglobin Elevations After Topical Applications of Benzocaine Alone or Benzocaine Plus Tetracaine to the Oral Mucosa. Clin Ther. 2017 Oct;39(10):2103-2108. doi: 10.1016/j.clinthera.2017.08.017. Epub 2017 Sep 22. PubMed PMID: 28943117.

9: Xia H, Attygalle AB. Untrapping Kinetically Trapped Ions: The Role of Water Vapor and Ion-Source Activation Conditions on the Gas-Phase Protomer Ratio of Benzocaine Revealed by Ion-Mobility Mass Spectrometry. J Am Soc Mass Spectrom. 2017 Dec;28(12):2580-2587. doi: 10.1007/s13361-017-1806-9. Epub 2017 Sep 21. PubMed PMID: 28936768.

10: Hutterer R. Inclusion of fluorophores in cyclodextrins: a closer look at the fluorometric determination of association constants by linear and nonlinear fitting procedures. Methods Appl Fluoresc. 2017 Dec 13;6(1):013001. doi: 10.1088/2050-6120/aa8d96. PubMed PMID: 28925371.

11: Lee HS. Recent advances in topical anesthesia. J Dent Anesth Pain Med. 2016 Dec;16(4):237-244. doi: 10.17245/jdapm.2016.16.4.237. Epub 2016 Dec 31. Review. PubMed PMID: 28879311; PubMed Central PMCID: PMC5564188.

12: Vohra R, Huntington S, Koike J, Le K, Geller RJ. Pediatric Exposures to Topical Benzocaine Preparations Reported to a Statewide Poison Control System. West J Emerg Med. 2017 Aug;18(5):923-927. doi: 10.5811/westjem.2017.6.33665. Epub 2017 Jul 14. PubMed PMID: 28874945; PubMed Central PMCID: PMC5576629.

13: Patel MA, AbouGhaly MHH, Chadwick K. The discovery and investigation of a crystalline solid solution of an active pharmaceutical ingredient. Int J Pharm. 2017 Oct 30;532(1):166-176. doi: 10.1016/j.ijpharm.2017.08.101. Epub 2017 Aug 25. PubMed PMID: 28847668.

14: Mohamed MA, Atty SA, Merey HA, Fattah TA, Foster CW, Banks CE. Titanium nanoparticles (TiO(2))/graphene oxide nanosheets (GO): an electrochemical sensing platform for the sensitive and simultaneous determination of benzocaine in the presence of antipyrine. Analyst. 2017 Oct 7;142(19):3674-3679. doi: 10.1039/c7an01101f. Epub 2017 Aug 24. PubMed PMID: 28836639.

15: Nahon S, Séité S, Kolasinski J, Aguirre P, Geurden I. Effects of euthanasia methods on stable carbon (δ(13) C value) and nitrogen (δ(15) N value) isotopic compositions of fry and juvenile rainbow trout Oncorhynchus mykiss. Rapid Commun Mass Spectrom. 2017 Oct 30;31(20):1742-1748. doi: 10.1002/rcm.7958. PubMed PMID: 28805256.

16: Sewell CR, Rivey MP. A Case Report of Benzocaine-Induced Methemoglobinemia. J Pharm Pract. 2017 Jan 1:897190017723211. doi: 10.1177/0897190017723211. [Epub ahead of print] PubMed PMID: 28803519.

17: Readman GD, Owen SF, Knowles TG, Murrell JC. Species specific anaesthetics for fish anaesthesia and euthanasia. Sci Rep. 2017 Aug 2;7(1):7102. doi: 10.1038/s41598-017-06917-2. PubMed PMID: 28769117; PubMed Central PMCID: PMC5541135.

18: Stringhetta GR, Barbas LAL, Maltez LC, Sampaio LA, Monserrat JM, Garcia LO. Oxidative stress responses of juvenile tambaqui Colossoma macropomum after short-term anesthesia with benzocaine and MS-222. An Acad Bras Cienc. 2017;89(3 Suppl):2209-2218. doi: 10.1590/0001-3765201720160823. Epub 2017 Jul 24. PubMed PMID: 28746612.

19: Chintala K, Kumar SP, Murthy KRV. Comparative evaluation of effectiveness of intra-pocket anesthetic gel and injected local anesthesia during scaling and root planing - A split-mouth clinical trial. Indian J Dent Res. 2017 May-Jun;28(3):281-285. doi: 10.4103/ijdr.IJDR_489_16. PubMed PMID: 28721992.

20: Skår MW, Haugland GT, Powell MD, Wergeland HI, Samuelsen OB. Development of anaesthetic protocols for lumpfish (Cyclopterus lumpus L.): Effect of anaesthetic concentrations, sea water temperature and body weight. PLoS One. 2017 Jul 5;12(7):e0179344. doi: 10.1371/journal.pone.0179344. eCollection 2017. PubMed PMID: 28678815; PubMed Central PMCID: PMC5497946.