WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341118

CAS#: 40456-50-6

Description: Yatein is a natural product isolated from from Cleistanthus boivinianu or Chamaecyparis obtusa. Yatein suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. The mechanisms of antiviral action of yatein seem to be mediated, by inhibiting HSV-1 α gene expression, including expression of the ICP0 and ICP4 genes, and by arresting HSV-1 DNA synthesis and structural protein expression in HeLa cells. Yatein showed antiproliferative activity against the HCT-116 human colon carcinoma cell line, with an IC50 > 10 uM.

Chemical Structure

CAS# 40456-50-6

Theoretical Analysis

MedKoo Cat#: 341118
Name: Yatein
CAS#: 40456-50-6
Chemical Formula: C22H24O7
Exact Mass: 400.15
Molecular Weight: 400.427
Elemental Analysis: C, 65.99; H, 6.04; O, 27.97

Price and Availability

Size Price Availability Quantity
5mg USD 750
10mg USD 1250
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Synonym: Yatein; Dihydroanhydropodorhizol.

IUPAC/Chemical Name: 2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)dihydro-3-((3,4,5-trimethoxyphenyl)methyl)-, trans-(-)-


InChi Code: InChI=1S/C22H24O7/c1-24-19-9-14(10-20(25-2)21(19)26-3)7-16-15(11-27-22(16)23)6-13-4-5-17-18(8-13)29-12-28-17/h4-5,8-10,15-16H,6-7,11-12H2,1-3H3/t15-,16+/m0/s1

SMILES Code: C1(=O)[C@@H]([C@H](CO1)Cc1cc2c(OCO2)cc1)Cc1cc(c(c(c1)OC)OC)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 400.427000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Picking D, Chambers B, Barker J, Shah I, Porter R, Naughton DP, Delgoda R. Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions. Molecules. 2018 Feb 15;23(2). pii: E430. doi: 10.3390/molecules23020430. PubMed PMID: 29462868. 2: Corbin C, Drouet S, Mateljak I, Markulin L, Decourtil C, Renouard S, Lopez T, Doussot J, Lamblin F, Auguin D, Lainé E, Fuss E, Hano C. Functional characterization of the pinoresinol-lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response. Planta. 2017 Apr 27. doi: 10.1007/s00425-017-2701-0. [Epub ahead of print] PubMed PMID: 28451749. 3: Liu Y, Young K, Rakotondraibe LH, Brodie PJ, Wiley JD, Cassera MB, Callmander MW, Rakotondrajaona R, Rakotobe E, Rasamison VE, TenDyke K, Shen Y, Kingston DG. Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest. 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PubMed PMID: 19329133. 13: Kuo YC, Kuo YH, Lin YL, Tsai WJ. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70(3):112-20. Epub 2006 Feb 20. PubMed PMID: 16540181. 14: Mohagheghzadeh A, Gholami A, Soltani M, Hemmati S, Alfermann AW. Linum mucronatum: organ to organ lignan variations. Z Naturforsch C. 2005 May-Jun;60(5-6):508-10. PubMed PMID: 16042353. 15: Usia T, Watabe T, Kadota S, Tezuka Y. Metabolite-cytochrome P450 complex formation by methylenedioxyphenyl lignans of Piper cubeba: mechanism-based inhibition. Life Sci. 2005 Apr 1;76(20):2381-91. PubMed PMID: 15748631. 16: Usia T, Watabe T, Kadota S, Tezuka Y. Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. PubMed PMID: 15679319. 17: Jang DS, Cuendet M, Su BN, Totura S, Riswan S, Fong HH, Pezzuto JM, Kinghorn AD. 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