WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555172

CAS#: 1357838-47-1

Description: UBP684 is a NMDAR pan-PAM (positive allosteric modulator) which robustly potentiates responses at all GluN1/GluN2 subtypes and at neuronal NMDARs. UBP684 increases the maximal l-glutamate/glycine response while having minor subunit-specific effects on agonist potency.

Chemical Structure

CAS# 1357838-47-1

Theoretical Analysis

MedKoo Cat#: 555172
Name: UBP684
CAS#: 1357838-47-1
Chemical Formula: C17H20O2
Exact Mass: 256.1463
Molecular Weight: 256.345
Elemental Analysis: C, 79.65; H, 7.86; O, 12.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: UBP684; UBP-684; UBP 684;

IUPAC/Chemical Name: 6-(4-methylpentyl)naphthalene-2-carboxylic acid


InChi Code: InChI=1S/C17H20O2/c1-12(2)4-3-5-13-6-7-15-11-16(17(18)19)9-8-14(15)10-13/h6-12H,3-5H2,1-2H3,(H,18,19)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 256.345 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chopra DA, Sapkota K, Irvine MW, Fang G, Jane DE, Monaghan DT, Dravid SM. A
single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA
receptors. Sci Rep. 2017 Jul 31;7(1):6933. doi: 10.1038/s41598-017-07292-8.
PubMed PMID: 28761055; PubMed Central PMCID: PMC5537304.

2: Sapkota K, Irvine MW, Fang G, Burnell ES, Bannister N, Volianskis A, Culley
GR, Dravid SM, Collingridge GL, Jane DE, Monaghan DT. Mechanism and properties of
positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl
2-naphthoic acid derivatives. Neuropharmacology. 2017 Oct;125:64-79. doi:
10.1016/j.neuropharm.2017.07.007. Epub 2017 Jul 11. PubMed PMID: 28709671; PubMed
Central PMCID: PMC5623084.