WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341099

CAS#: 13027-33-3

Description: Yakkasterone is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone.

Chemical Structure

CAS# 13027-33-3

Theoretical Analysis

MedKoo Cat#: 341099
Name: Yakkasterone
CAS#: 13027-33-3
Chemical Formula: C27H46O3
Exact Mass: 418.3447
Molecular Weight: 418.662
Elemental Analysis: C, 77.46; H, 11.08; O, 11.46

Price and Availability

Size Price Availability Quantity
1.0mg USD 190.0 2 Weeks
10.0mg USD 680.0 2 Weeks
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Synonym: Yakkasterone; YS 64.

IUPAC/Chemical Name: Cholestan-6-one, 3,5-dihydroxy-, (3beta,5alpha)-


InChi Code: InChI=1S/C27H46O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-23,28,30H,6-16H2,1-5H3/t18-,19+,20+,21+,22+,23-,25-,26+,27+/m1/s1

SMILES Code: C1[C@@H](C[C@@]2(C(C[C@H]3[C@@H]4CC[C@@H]([C@@H](CCCC(C)C)C)[C@@]4(C)CC[C@H]3[C@@]2(C1)C)=O)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 418.662 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yamaguchi M, Endo Y, Shimizu M, Yamamoto K, Yamada S, Shudo K. 3 beta,5 alpha-Dihydroxycholestan-6-one exists in human blood. Biol Pharm Bull. 1997 Sep;20(9):1044-6. PubMed PMID: 9331996.

2: Matsushima Y, Fukasawa H, Endo Y, Hashimoto Y, Shudo K. Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 alpha-dihydroxycholestan-6-one, and cholesterol. Biol Pharm Bull. 1994 Sep;17(9):1292-5. PubMed PMID: 7841956.

3: Endo Y, Hashimoto Y, Fukasawa H, Shudo K. Oxygenated cholesterols as ligands for cytosolic-nuclear tumor promoter binding protein: yakkasteroids. Biochem Biophys Res Commun. 1993 Aug 16;194(3):1529-35. PubMed PMID: 8352811.