WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 341072
Description: Y-23684 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.
MedKoo Cat#: 341072
Name: Y 23684
Chemical Formula: C18H13ClN2O2S
Exact Mass: 356.0386
Molecular Weight: 356.824
Elemental Analysis: C, 60.59; H, 3.67; Cl, 9.93; N, 7.85; O, 8.97; S, 8.98
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Y 23684; Y-23684; Y23684.
IUPAC/Chemical Name: (1)Benzothiepino(5,4-c)pyridazin-3(2H)-one, 2-(4-chlorophenyl)-5,6-dihydro-, 7-oxide
InChi Key: WHMCSFWQVGJBGM-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H13ClN2O2S/c19-13-5-7-14(8-6-13)21-17(22)11-12-9-10-24(23)16-4-2-1-3-15(16)18(12)20-21/h1-8,11H,9-10H2
SMILES Code: c1ccc2c(c1)-c3c(cc(=O)n(n3)c4ccc(cc4)Cl)CCS2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 356.824 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ. Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands. Behav Pharmacol. 1999 Sep;10(5):483-95. PubMed PMID: 10780255.
2: Y 23684. Drugs R D. 1999 Jul;2(1):68-9. PubMed PMID: 10610289.
3: Griebel G, Perrault G, Sanger DJ. Differences in anxiolytic-like profile of two novel nonbenzodiazepine BZ (omega) receptor agonists on defensive behaviors of mice. Pharmacol Biochem Behav. 1999 Apr;62(4):689-94. PubMed PMID: 10208374.
4: Yasumatsu H, Morimoto Y, Yamamoto Y, Takehara S, Fukuda T, Nakao T, Setoguchi M. The pharmacological properties of Y-23684, a benzodiazepine receptor partial agonist. Br J Pharmacol. 1994 Apr;111(4):1170-8. PubMed PMID: 7913372; PubMed Central PMCID: PMC1910153.
5: Yakushiji T, Shirasaki T, Munakata M, Hirata A, Akaike N. Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurones. Br J Pharmacol. 1993 Jul;109(3):819-25. PubMed PMID: 8395299; PubMed Central PMCID: PMC2175650.
6: Samemoto H, Yamada I, Yata T, Ogawa K. Powder coating mixture of a novel anxiolytic, Y-23684: dissolution characteristics and bioavailability. Chem Pharm Bull (Tokyo). 1992 Apr;40(4):1007-10. PubMed PMID: 1356081.
7: Nakao T, Obata M, Yamaguchi Y, Marubayashi N, Ikeda K, Morimoto Y. Synthesis and biological activities of optical isomers of 2-(4-chlorophenyl)-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-o ne 7-oxide. Chem Pharm Bull (Tokyo). 1992 Jan;40(1):117-21. PubMed PMID: 1349512.
8: Nakao T, Obata M, Kawakami M, Morita K, Tanaka H, Morimoto Y, Takehara S, Yakushiji T, Tahara T. Studies on the synthesis of condensed pyridazine derivatives. IV. Synthesis and anxiolytic activity of 2-aryl-5,6-dihydro-(1)benzothiepino[5,4- c]pyridazin-3(2H)-ones and related compound. Chem Pharm Bull (Tokyo). 1991 Oct;39(10):2556-63. PubMed PMID: 1687209.