D714

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581091

CAS#: 63906-31-0

Description: D714 is a weakly conserved palm-subdomain residue (located distant from the catalytic center), when replaced with alanine, impairs the replicative functions of the enzyme both in vivo and in vitro.


Price and Availability

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D714 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581091
Name: D714
CAS#: 63906-31-0
Chemical Formula: C21H28ClN3OS2
Exact Mass: 437.1362
Molecular Weight: 438.04
Elemental Analysis: C, 57.58; H, 6.44; Cl, 8.09; N, 9.59; O, 3.65; S, 14.64


Synonym: D714; D 714; D-714;

IUPAC/Chemical Name: 10H-Pyrido(3,2-b)(1,4)benzothiazine-10-carbothioic acid, S-((2-diisopropylamino-1-methyl)ethyl) ester, hydrochloride

InChi Key: JEBZXFIOPYWIRH-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27N3OS2.ClH/c1-14(2)23(15(3)4)13-16(5)26-21(25)24-17-9-6-7-10-18(17)27-19-11-8-12-22-20(19)24;/h6-12,14-16H,13H2,1-5H3;1H

SMILES Code: O=C(N1C2=NC=CC=C2SC3=CC=CC=C13)SC(C)CN(C(C)C)C(C)C.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Jacewicz A, Trzemecka A, Guja KE, Plochocka D, Yakubovskaya E, Bebenek A, Garcia-Diaz M. A remote palm domain residue of RB69 DNA polymerase is critical for enzyme activity and influences the conformation of the active site. PLoS One. 2013 Oct 7;8(10):e76700. doi: 10.1371/journal.pone.0076700. eCollection 2013. PubMed PMID: 24116139; PubMed Central PMCID: PMC3792054.

2: Tanaka A, Katsuno T, Ozaki T, Sakata F, Kato N, Suzuki Y, Kosugi T, Kato S, Tsuboi N, Sato W, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S. The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. Acta Cardiol. 2015 Apr;70(2):217-23. PubMed PMID: 26148383.

3: Wang K, Sitsel O, Meloni G, Autzen HE, Andersson M, Klymchuk T, Nielsen AM, Rees DC, Nissen P, Gourdon P. Structure and mechanism of Zn2+-transporting P-type ATPases. Nature. 2014 Oct 23;514(7523):518-22. doi: 10.1038/nature13618. Epub 2014 Aug 17. PubMed PMID: 25132545; PubMed Central PMCID: PMC4259247.

4: Poelchau M, Childers C, Moore G, Tsavatapalli V, Evans J, Lee CY, Lin H, Lin JW, Hackett K. The i5k Workspace@NAL--enabling genomic data access, visualization and curation of arthropod genomes. Nucleic Acids Res. 2015 Jan;43(Database issue):D714-9. doi: 10.1093/nar/gku983. Epub 2014 Oct 20. PubMed PMID: 25332403; PubMed Central PMCID: PMC4384035.

5: Lloyd SA, Lang CH, Zhang Y, Paul EM, Laufenberg LJ, Lewis GS, Donahue HJ. Interdependence of muscle atrophy and bone loss induced by mechanical unloading. J Bone Miner Res. 2014;29(5):1118-30. doi: 10.1002/jbmr.2113. PubMed PMID: 24127218; PubMed Central PMCID: PMC4074925.

6: Zarocostas J. Donor countries have responsibility to root out corruption in aid flows. BMJ. 2011 Feb 2;342:d714. doi: 10.1136/bmj.d714. PubMed PMID: 21289010.

7: Walschus U, Hoene A, Patrzyk M, Finke B, Polak M, Lucke S, Nebe B, Schroeder K, Podbielski A, Wilhelm L, Schlosser M. Serum profile of pro- and anti-inflammatory cytokines in rats following implantation of low-temperature plasma-modified titanium plates. J Mater Sci Mater Med. 2012 May;23(5):1299-307. doi: 10.1007/s10856-012-4600-z. Epub 2012 Mar 9. PubMed PMID: 22402792.

8: Lemon HM, Rodriguez-Sierra JF. Timing of breast cancer surgery during the luteal menstrual phase may improve prognosis. Nebr Med J. 1996 Mar;81(3):73-8. Corrected and republished in: Nebr Med J. 1996 Apr;81(4):110-5. PubMed PMID: 8907825.

9: Choi J, Cheong K, Jung K, Jeon J, Lee GW, Kang S, Kim S, Lee YW, Lee YH. CFGP 2.0: a versatile web-based platform for supporting comparative and evolutionary genomics of fungi and Oomycetes. Nucleic Acids Res. 2013 Jan;41(Database issue):D714-9. doi: 10.1093/nar/gks1163. Epub 2012 Nov 27. PubMed PMID: 23193288; PubMed Central PMCID: PMC3531191.

10: Kalli KR, Conover CA. The insulin-like growth factor/insulin system in epithelial ovarian cancer. Front Biosci. 2003 May 1;8:d714-22. Review. PubMed PMID: 12700030.