D 595

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581087

CAS#: 16740-29-7

Description: D595 (10(-5) M), is a phenethylamine-type calcium channel blocker. The most potent phenylalkylamine with respect to negative inotropy was (+/-)-D 595 with an EC50-value of 794 nmol/l.

Chemical Structure

D 595
CAS# 16740-29-7

Theoretical Analysis

MedKoo Cat#: 581087
Name: D 595
CAS#: 16740-29-7
Chemical Formula: C25H32Cl2N2O2
Exact Mass: 462.1841
Molecular Weight: 463.44
Elemental Analysis: C, 64.79; H, 6.96; Cl, 15.30; N, 6.04; O, 6.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: D 595; D-595; D595;

IUPAC/Chemical Name: Benzeneacetonitrile, 3,4-dichloro-alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-alpha-(1-methylethyl)-


InChi Code: InChI=1S/C25H32Cl2N2O2/c1-18(2)25(17-28,20-8-9-21(26)22(27)16-20)12-6-13-29(3)14-11-19-7-10-23(30-4)24(15-19)31-5/h7-10,15-16,18H,6,11-14H2,1-5H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 463.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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5: Clark JM, Brooks MW. Role of ion channels and intraterminal calcium homeostasis in the action of deltamethrin at presynaptic nerve terminals. Biochem Pharmacol. 1989 Jul 15;38(14):2233-45. PubMed PMID: 2546560.

6: Goll A, Glossmann H, Mannhold R. Correlation between the negative inotropic potency and binding parameters of 1,4-dihydropyridine and phenylalkylamine calcium channel blockers in cat heart. Naunyn Schmiedebergs Arch Pharmacol. 1986 Nov;334(3):303-12. PubMed PMID: 3027587.