PA-9

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562158

CAS#: 1436004-46-4

Description: PA-9 is the first small-molecule antagonist of the PAC1 receptor.


Price and Availability

Size
Price

Size
Price

Size
Price

PA-9 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 562158
Name: PA-9
CAS#: 1436004-46-4
Chemical Formula: C17H18N6O2
Exact Mass: 338.1491
Molecular Weight: 338.37
Elemental Analysis: C, 60.34; H, 5.36; N, 24.84; O, 9.46


Synonym: PA-9; PA 9; PA9;

IUPAC/Chemical Name: N-[2-(1H-Imidazol-4-yl)ethyl]-1-(2H-indazol-3-yl)-5-oxopyrrolidine-3-carboxamide

InChi Key: WWPHFXOMYQJGGF-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18N6O2/c24-15-7-11(17(25)19-6-5-12-8-18-10-20-12)9-23(15)16-13-3-1-2-4-14(13)21-22-16/h1-4,8,10-11H,5-7,9H2,(H,18,20)(H,19,25)(H,21,22)

SMILES Code: O=C(C(C1)CN(C2=C3C=CC=CC3=NN2)C1=O)NCCC4=CNC=N4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Takasaki I, Watanabe A, Yokai M, Watanabe Y, Hayakawa D, Nagashima R, Fukuchi M, Okada T, Toyooka N, Miyata A, Gouda H, Kurihara T. In silico screening identified novel small-molecule antagonists of PAC1 receptor. J Pharmacol Exp Ther. 2018 Jan 23. pii: jpet.117.245415. doi: 10.1124/jpet.117.245415. [Epub ahead of print] PubMed PMID: 29363578.

2: Maslennikova IL, Kuznetsova MV, Nekrasova IV, Shirshev SV. Effect of bacterial components of mixed culture supernatants of planktonic and biofilm Pseudomonas aeruginosa with commensal Escherichia coli on the neutrophil response in vitro. Pathog Dis. 2017 Nov 30;75(8). doi: 10.1093/femspd/ftx105. PubMed PMID: 28961860.

3: Demmelmaier I, Björk A, Dufour AB, Nordgren B, Opava CH. Trajectories of fear-avoidance beliefs on physcial activity over two years in people with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2017 Sep 21. doi: 10.1002/acr.23419. [Epub ahead of print] PubMed PMID: 28941003.

4: Dwyer KM, Clark CJ, MacDonald K, Paraskeva MA, Rogers N, Ryan J, Webster AC, Wong G. Gender Equity in Transplantation: A Report from the Women in Transplantation Workshop of The Transplantation Society of Australia and New Zealand. Transplantation. 2017 Oct;101(10):2266-2270. doi: 10.1097/TP.0000000000001900. PubMed PMID: 28767533.

5: Colla-Machado PE, Pigretti SG, Luzzi AA, Balian NR, Cristiano E, Zurru-Ganen MC. [Is endovenous thrombolysis safety and efficacy in ischemic stroke comparable between patients aged over and above 80 years? Experience from an Argentinean cohort]. Rev Neurol. 2017 Apr 16;64(8):347-352. Spanish. PubMed PMID: 28368081.

6: Jibiri NN, Olowookere CJ. Evaluation of dose-area product of common radiographic examinations towards establishing a preliminary diagnostic reference levels (PDRLs) in Southwestern Nigeria. J Appl Clin Med Phys. 2016 Nov 8;17(6):392-404. doi: 10.1120/jacmp.v17i6.6011. PubMed PMID: 27929511.

7: Hata M, Orime Y, Wakui S, Nakamura T, Hinoura R, Akiyama K. Efficacy of limited proximal arch replacement for type A acute aortic dissection with critical complications. Gen Thorac Cardiovasc Surg. 2016 Nov;64(11):651-656. Epub 2016 Jul 18. PubMed PMID: 27431991.

8: Husu P, Suni J, Vähä-Ypyä H, Sievänen H, Tokola K, Valkeinen H, Mäki-Opas T, Vasankari T. Objectively measured sedentary behavior and physical activity in a sample of Finnish adults: a cross-sectional study. BMC Public Health. 2016 Sep 1;16:920. doi: 10.1186/s12889-016-3591-y. PubMed PMID: 27586887; PubMed Central PMCID: PMC5009485.

9: Freeman MA, Pleis JR, Bornemann KR, Croswell E, Dew MA, Chang CH, Switzer GE, Langone A, Mittal-Henkle A, Saha S, Ramkumar M, Adams Flohr J, Thomas CP, Myaskovsky L. Has the Department of Veterans Affairs Found a Way to Avoid Racial Disparities in the Evaluation Process for Kidney Transplantation? Transplantation. 2017 Jun;101(6):1191-1199. doi: 10.1097/TP.0000000000001377. PubMed PMID: 27482965; PubMed Central PMCID: PMC5288397.

10: Sanders JP, Loveday A, Pearson N, Edwardson C, Yates T, Biddle SJ, Esliger DW. Devices for Self-Monitoring Sedentary Time or Physical Activity: A Scoping Review. J Med Internet Res. 2016 May 4;18(5):e90. doi: 10.2196/jmir.5373. Review. PubMed PMID: 27145905; PubMed Central PMCID: PMC4871995.

11: Dew MA, Rosenberger EM, Myaskovsky L, DiMartini AF, DeVito Dabbs AJ, Posluszny DM, Steel J, Switzer GE, Shellmer DA, Greenhouse JB. Depression and Anxiety as Risk Factors for Morbidity and Mortality After Organ Transplantation: A Systematic Review and Meta-Analysis. Transplantation. 2015 May;100(5):988-1003. doi: 10.1097/TP.0000000000000901. Review. PubMed PMID: 26492128; PubMed Central PMCID: PMC4840103.

12: Kim JH, Roberge RJ, Powell JB. Effect of external airflow resistive load on postural and exercise-associated cardiovascular and pulmonary responses in pregnancy: a case control study. BMC Pregnancy Childbirth. 2015 Feb 22;15:45. doi: 10.1186/s12884-015-0474-7. PubMed PMID: 25886031; PubMed Central PMCID: PMC4357216.

13: Donath L, Roth R, Zahner L, Faude O. Slackline training and neuromuscular performance in seniors: A randomized controlled trial. Scand J Med Sci Sports. 2016 Mar;26(3):275-83. doi: 10.1111/sms.12423. Epub 2015 Mar 10. PubMed PMID: 25756231.

14: De Baere S, Seghers J, Philippaerts R, De Martelaer K, Lefevre J. Intensity- and Domain-Specific Levels of Physical Activity and Sedentary Behavior in 10- to 14-Year-Old Children. J Phys Act Health. 2015 Dec;12(12):1543-50. doi: 10.1123/jpah.2014-0416. Epub 2015 Mar 5. PubMed PMID: 25742313.

15: Courneya KS, Rogers LQ, Campbell KL, Vallance JK, Friedenreich CM. Top 10 research questions related to physical activity and cancer survivorship. Res Q Exerc Sport. 2015 Jun;86(2):107-16. doi: 10.1080/02701367.2015.991265. Epub 2015 Jan 28. PubMed PMID: 25629322.

16: Ouaïssi M, Silvy F, Loncle C, Ferraz da Silva D, Martins Abreu C, Martinez E, Berthézene P, Cadra S, Le Treut YP, Hardwigsen J, Sastre B, Sielezneff I, Benkoel L, Delgrande J, Ouaissi A, Iovanna J, Lombardo D, Mas E. Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome. PLoS One. 2014 Oct 2;9(9):e108520. doi: 10.1371/journal.pone.0108520. eCollection 2014. PubMed PMID: 25275504; PubMed Central PMCID: PMC4183483.

17: Ishii K, Shibata A, Sato M, Oka K. Recess physical activity and perceived school environment among elementary school children. Int J Environ Res Public Health. 2014 Jul 15;11(7):7195-206. doi: 10.3390/ijerph110707195. PubMed PMID: 25029495; PubMed Central PMCID: PMC4113870.

18: Xie L, Chen JL, Zhang WZ, Wang SZ, Zhao TL, Huang C, Wang J, Yang JF, Yang YF, Tan ZP. Rare de novo copy number variants in patients with congenital pulmonary atresia. PLoS One. 2014 May 14;9(5):e96471. doi: 10.1371/journal.pone.0096471. eCollection 2014. PubMed PMID: 24826987; PubMed Central PMCID: PMC4020819.

19: Deng MC, Elashoff B, Pham MX, Teuteberg JJ, Kfoury AG, Starling RC, Cappola TP, Kao A, Anderson AS, Cotts WG, Ewald GA, Baran DA, Bogaev RC, Shahzad K, Hiller D, Yee J, Valantine HA; IMAGE Study Group. Utility of gene expression profiling score variability to predict clinical events in heart transplant recipients. Transplantation. 2014 Mar 27;97(6):708-14. doi: 10.1097/01.TP.0000443897.29951.cf. PubMed PMID: 24637869; PubMed Central PMCID: PMC3983476.

20: Adeoye O, Knight WA, Khoury J, Schmit PA, Sucharew H, Broderick JP, Pancioli AM; CLEAR-ER Investigators. A matched comparison of eptifibatide plus rt-PA versus rt-PA alone in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):e313-5. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.012. Epub 2014 Feb 15. PubMed PMID: 24534128; PubMed Central PMCID: PMC4035416.