XDM-CBP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562145

CAS#: 2138461-99-9

Description: XDM-CBP is a highly potent and selective inhibitor of CBP/p300 bromodomain.


Price and Availability

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XDM-CBP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562145
Name: XDM-CBP
CAS#: 2138461-99-9
Chemical Formula: C21H22N2O4
Exact Mass: 366.158
Molecular Weight: 366.41
Elemental Analysis: C, 68.84; H, 6.05; N, 7.65; O, 17.47


Synonym: XDM-CBP; XDM CBP; XDMCBP;

IUPAC/Chemical Name: 4-Acetyl-N-((2,8-dihydroxynaphthalen-1-yl)methyl)-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide

InChi Key: KCGVENSOXCWCNF-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22N2O4/c1-4-14-18(12(3)24)11(2)23-20(14)21(27)22-10-15-16(25)9-8-13-6-5-7-17(26)19(13)15/h5-9,23,25-26H,4,10H2,1-3H3,(H,22,27)

SMILES Code: O=C(C1=C(CC)C(C(C)=O)=C(C)N1)NCC2=C3C(O)=CC=CC3=CC=C2O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hügle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung M, Breit B, Günther S, Wohlwend D. Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12476-12480. doi: 10.1002/anie.201705516. Epub 2017 Sep 7. PubMed PMID: 28766825.