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MedKoo CAT#: 562144

CAS#: 1374647-07-0

Description: L458-BPyne is a γ-secretase modulator photoaffinity probe. It acts by identifying distinct allosteric binding sites on presenilin that can be exploited to reduce levels of pathogenic Aβ species.

Price and Availability

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Pricing updated 2020-04-07. Prices are subject to change without notice.

L458-BPyne is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 562144
Name: L458-BPyne
CAS#: 1374647-07-0
Chemical Formula: C52H64N4O7
Exact Mass: 856.4775
Molecular Weight: 857.1
Elemental Analysis: C, 72.87; H, 7.53; N, 6.54; O, 13.07

Synonym: L458-BPyne; L458 BPyne; L458BPyne;

IUPAC/Chemical Name: tert-butyl ((2S,3R,5R)-6-(((S)-1-((S)-3-(4-benzoylphenyl)-2-(hex-5-yn-1-ylamino)propanamido)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate


InChi Code: InChI=1S/C52H64N4O7/c1-7-8-9-19-30-53-44(34-39-26-28-41(29-27-39)47(58)40-24-17-12-18-25-40)49(60)56-50(61)45(31-36(2)3)54-48(59)42(32-37-20-13-10-14-21-37)35-46(57)43(33-38-22-15-11-16-23-38)55-51(62)63-52(4,5)6/h1,10-18,20-29,36,42-46,53,57H,8-9,19,30-35H2,2-6H3,(H,54,59)(H,55,62)(H,56,60,61)/t42-,43+,44+,45+,46-/m1/s1

SMILES Code: O=C(OC(C)(C)C)N[C@H]([C@H](O)C[C@@H](CC1=CC=CC=C1)C(N[C@H](C(NC([C@@H](NCCCCC#C)CC2=CC=C(C(C3=CC=CC=C3)=O)C=C2)=O)=O)CC(C)C)=O)CC4=CC=CC=C4

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: