D4DAP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581083

CAS#: 109881-25-6

Description: D4DAP is HIV virus replication inhibitor.


Price and Availability

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Price

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D4DAP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581083
Name: D4DAP
CAS#: 109881-25-6
Chemical Formula: C10H12N6O2
Exact Mass: 248.1022
Molecular Weight: 248.25
Elemental Analysis: C, 48.38; H, 4.87; N, 33.85; O, 12.89


Synonym: D4DAP; Ddedapr;

IUPAC/Chemical Name: Adenosine, 2-amino-2',3'-didehydro-2',3'-dideoxy-

InChi Key: QVRGWJZTKCMSIW-NTSWFWBYSA-N

InChi Code: QVRGWJZTKCMSIW-NTSWFWBYSA-N

SMILES Code: OC[C@@H]1C=C[C@H](N2C=NC3=C(N=C(N)N=C32)N)O1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Balzarini J, Robins MJ, Zou RM, Herdewijn P, De Clercq E. The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication. Biochem Biophys Res Commun. 1987 May 29;145(1):277-83. PubMed PMID: 3496090.

2: Balzarini J, De Clercq E. The antiviral activity of 9-beta-D-arabinofuranosyladenine is enhanced by the 2',3'-dideoxyriboside, the 2',3'-didehydro-2',3'-dideoxyriboside and the 3'-azido-2',3'-dideoxyriboside of 2,6-diaminopurine. Biochem Biophys Res Commun. 1989 Feb 28;159(1):61-7. PubMed PMID: 2538128.

3: Balzarini J, Pauwels R, Baba M, Robins MJ, Zou RM, Herdewijn P, De Clercq E. The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro. Biochem Biophys Res Commun. 1987 May 29;145(1):269-76. PubMed PMID: 3496089.