WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581081
Description: D21-2393 is known as Edoxaban 4-Carboxylic Acid. Subjects received a single-oral-dose of edoxaban 30-90 mg in each study occasion under fasting condition. Serial blood samples were collected to measure the plasma concentrations of edoxaban and its major active metabolite D21-2393. Meanwhile, PT, INR, aPTT were measured pre- and post-dose. Safety was assessed. 4. The effects of edoxaban on all pharmacodynamic biomarkers were concentration-dependent and linearly-correlated to plasma level of the compound. Minor bleeding was the most commonly reported adverse events.
MedKoo Cat#: 581081
Chemical Formula: C22H25ClN6O5S
Exact Mass: 520.1296
Molecular Weight: 520.99
Elemental Analysis: C, 50.72; H, 4.84; Cl, 6.80; N, 16.13; O, 15.35; S, 6.15
Synonym: D21-2393; D21 2393; UNII-IV344R972X; Edoxaban 4-Carboxylic Acid;
IUPAC/Chemical Name: Cyclohexanecarboxylic acid, 4-((2-((5-chloro-2-pyridinyl)amino)-2-oxoacetyl)amino)-3-(((4,5,6,7-tetrahydro-5-methylthiazolo(5,4-C)pyridin-2-yl)carbonyl)amino)-, (1S,3R,4S)-
InChi Key: QPYMJNYAASVNAP-CORIIIEPSA-N
InChi Code: InChI=1S/C22H25ClN6O5S/c1-29-7-6-14-16(10-29)35-21(27-14)20(32)26-15-8-11(22(33)34)2-4-13(15)25-18(30)19(31)28-17-5-3-12(23)9-24-17/h3,5,9,11,13,15H,2,4,6-8,10H2,1H3,(H,25,30)(H,26,32)(H,33,34)(H,24,28,31)/t11-,13-,15+/m0/s1
SMILES Code: O=C([C@@H]1C[C@@H](NC(C(S2)=NC3=C2CN(C)CC3)=O)[C@@H](NC(C(NC4=NC=C(Cl)C=C4)=O)=O)CC1)O
1: Chen X, Liu D, Wu Y, Song H, Liu Y, Jiang J, Hu P. A single-dose study investigating the pharmacokinetics and pharmacodynamics of edoxaban at 30-90 mg in healthy Chinese volunteers. Xenobiotica. 2017 Jul;47(7):592-599. doi: 10.1080/00498254.2016.1207825. Epub 2016 Aug 25. PubMed PMID: 27560456.
2: Chen X, Liu D, Wu Y, Liu Y, Song H, Jiang J, Hu P. A single and multiple postprandial dose study investigating the pharmacokinetics and pharmacodynamics of edoxaban in healthy Chinese volunteers . Int J Clin Pharmacol Ther. 2017 Mar;55(3):256-263. doi: 10.5414/CP202737. PubMed PMID: 28025966.