G-9791

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562130

CAS#: 1926204-95-6

Description: G-9791 is a potent and selective group-I PAK (pan-PAK1/2/3) inhibitor.


Price and Availability

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Price

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G-9791 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562130
Name: G-9791
CAS#: 1926204-95-6
Chemical Formula: C26H26ClFN6O2
Exact Mass: 508.179
Molecular Weight: 508.98
Elemental Analysis: C, 61.35; H, 5.15; Cl, 6.96; F, 3.73; N, 16.51; O, 6.29


Synonym: G-9791; G 9791; G9791;

IUPAC/Chemical Name: 6-(2-Chloro-4-(3-methyl-2-oxopyridin-1(2H)-yl)phenyl)-8-(2-(3-fluoro-1-methylazetidin-3-yl)ethyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

InChi Key: KHDMDYBLHAGOQS-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H26ClFN6O2/c1-16-5-4-9-33(23(16)35)18-6-7-19(21(27)12-18)20-11-17-13-30-25(29-2)31-22(17)34(24(20)36)10-8-26(28)14-32(3)15-26/h4-7,9,11-13H,8,10,14-15H2,1-3H3,(H,29,30,31)

SMILES Code: O=C1C(C2=CC=C(N3C=CC=C(C)C3=O)C=C2Cl)=CC4=CN=C(NC)N=C4N1CCC5(F)CN(C)C5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Rudolph J, Murray LJ, Ndubaku CO, O'Brien T, Blackwood E, Wang W, Aliagas I, Gazzard L, Crawford JJ, Drobnick J, Lee W, Zhao X, Hoeflich KP, Favor DA, Dong P, Zhang H, Heise CE, Oh A, Ong CC, La H, Chakravarty P, Chan C, Jakubiak D, Epler J, Ramaswamy S, Vega R, Cain G, Diaz D, Zhong Y. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41. doi: 10.1021/acs.jmedchem.6b00638. Epub 2016 May 24. PubMed PMID: 27167326.